Results 241 to 250 of about 28,369,893 (296)

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Nipah virus Malaysia and Bangladesh strain-induced pathogenesis in mice lacking type I interferon receptor signaling. [PDF]

PLoS Negl Trop Dis
Amurri L, Reynard O, Ronco I, Déri D, Pályi B, Spanier J, Skerra J, Terceve O, Larcher T, Kalinke U, Kis Z, Horvat B, Iampietro M.   +12 more
europepmc   +1 more source

The plasmacytoid dendritic cell paradox in cancer: impaired type I interferon responses in a nucleic acid-rich tumor microenvironment. [PDF]

Front Immunol
Vasilakou A, Loizon S, Dubois M, Laurent P, Sisirak V, Duluc D.   +5 more
europepmc   +1 more source

mTORC1 Promotes SARS-CoV-2 Replication and Attenuates Type I Interferon Responses in the Alveolar Epithelium: A Computational and Experimental Study. [PDF]

Bull Math Biol
Kutuva AR, Ribeiro HA, Lima FT, Schaller MA, Mehrad B, Laubenbacher R.   +5 more
europepmc   +1 more source

Specific bile acids can elicit the type-I interferon response through the cGAS-STING pathway. [PDF]

Cell Commun Signal
He J, Huang Z, Xiong C, Huang Z, Yan H, Sun B, Liu X, Cao Y, Chen X, Li H, Cao L, Xiao H.   +11 more
europepmc   +1 more source

Disruption of macrophage cell volume drives inflammatory responses and type I interferon signaling. [PDF]

J Cell Biol
Cook JR, Gleeson TA, Gago S, Allan SM, Couper KN, Lawrence CB, Brough D, Green JP.   +7 more
europepmc   +1 more source

Gut microbiota functional remodeling and butyrate depletion amplify anti-Ro/La antibody-driven type I interferon activation in neonatal lupus. [PDF]

Gut Microbes
Sun W, Li Y, Liu X, Yu S, Li W, Wang H, Geng H, Li L, Hu J, Huo J, Zhang W, Fu J, Jin X, Li H, Zhou X, Zhu X.   +15 more
europepmc   +1 more source