Results 241 to 250 of about 521,269 (357)

Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells. [PDF]

Immunity
Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Ullrich S, Yeung ST, Tan Y, Pucella JN, Dolgalev I, Levy DE, Khanna KM, Solovei I, Mirny LA, Reizis B.   +14 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Inhibition of type I interferon signaling is a conserved function of gamma-herpesvirus-encoded microRNAs. [PDF]

J Virol
Fachko DN, Chen Y, Ivanov NS, Goff B, Pendergrass B, Oldenburg DG, Estep RD, Wong SW, Skalsky RL.   +8 more
europepmc   +1 more source

Vitamin D Potentiates the Inhibitory Effect of MicroRNA‐130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway [PDF]

, 2015
Xiaoqiong Duan, Yujuan Guan, Yujia Li, Shan Chen, Shilin Li, Limin Chen   +5 more
openalex   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Increased Type I Interferon Activity with Concurrent Plasmablast Expansion Identifies Systemic Lupus Erythematosus Patients with Poor Outcomes. [PDF]

Int J Mol Sci
Speidel K, Cheng Q, Khodadadi L, Sinzinger B, Martin J, Beenken AE, Biesen R, Krönke G, Hiepe F, Alexander T.   +9 more
europepmc   +1 more source

Reviewer #2 (Public Review): Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

Jianwen Chen, Bao Zhao, Hong Dong, Tianliang Li, Xiang Cheng, Wang Gong, Jing Wang, Junran Zhang, Gang Xin, Yanbao Yu, Yu L Lei, Jennifer D Black, Zihai Li, Haitao Wen   +13 more
openalex   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Type I interferon signaling defines a novel disease signature in xeroderma pigmentosum C human keratinocytes. [PDF]

Sci Rep
Nasrallah A, Rezvani HR, Belmudes L, Bourgoin-Voillard S, Kobaisi F, Fayyad-Kazan M, Seve M, Couté Y, Sulpice E, Rachidi W.   +9 more
europepmc   +1 more source