Results 261 to 270 of about 521,269 (357)

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases. [PDF]

Front Immunol
Panlu K, Wang Y, Zhu X, Lin Z, Fang T, Yao X, Xie Z, Wang X.   +7 more
europepmc   +1 more source

PEP-R619W Distinctly Modulates Persistent Type-I Interferon Signaling to enhance DC and CD8 T cell function 4147 [PDF]

Anam Fatima Shaikh, Jenna Barnes, Tammy Cockerham, Nancy Schwarting, Robin C. Orozco   +4 more
openalex   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Validation of Recombinant Type I Interferon Antiviral Activity Against Porcine Epidemic Diarrhea Virus In Vitro and In Vivo. [PDF]

Vet Sci
Du L, Zhang R, Wang S, Han S, Zhang S, Meng F, Fang Z, Wang X, Zhao R, Dai R, Qin L, Lyu C, Wang G.   +12 more
europepmc   +1 more source

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Semaphorin 6D drives anti-tumor type I interferon responses to reprogram the tumor microenvironment in colorectal cancer. [PDF]

Cell Death Dis
Shi W, Zhang F, Sun WQ, Liang LQ, Krishnan S.   +4 more
europepmc   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

HCMV encoded UL84 hijacks FHL2 to suppress type I interferon production and enhance viral replication. [PDF]

PLoS Pathog
Li R, Xia S, Li X, Zeng Y, Wang T, Xia C, Li H, Chen J.   +7 more
europepmc   +1 more source

Downregulation of IRF7-mediated type-I interferon response by LmCen–/– parasites is necessary for protective immunity [PDF]

Telly Sepahpour, Jalal Alshaweesh, Nazli Azodi, Komudi Singh, Derek D.C. Ireland, Farzaneh Valanezhad, Risa Nakamura, Abhay R. Satoskar, Ranadhir Dey, Shinjiro Hamano, Hira L. Nakhasi, Sreenivas Gannavaram   +11 more
openalex   +1 more source