Results 251 to 260 of about 28,369,893 (296)

TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasis

Sharma N, Tanwar A, Zheng C, Ambudkar I, Motiani RK.   +4 more
europepmc   +1 more source

Loss of MTPAP disrupts mitochondrial RNA processing causing upregulation of type I interferon signalling

Pierga A, de Souza Angelo Y, Safieddine A, Benassy M, Didry-Barca B, Rozen M, Seabra L, Lovo C, Bannwarth S, Lacas-Gervais S, Kollberg G, Hedberg-Oldfors C, Savvidou A, Weil D, Crow YJ, Lepelley A.   +15 more
europepmc   +1 more source

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Type I Interferons in Autoimmunity

Journal of Investigative Dermatology, 2022
Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies ...
Ruth Fernandez-Ruiz, Timothy B. Niewold
openaire   +2 more sources

Type I interferon in rheumatic diseases [PDF]

Nature Reviews Rheumatology, 2018
The type I interferon pathway has been implicated in the pathogenesis of a number of rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis, systemic sclerosis, and rheumatoid arthritis. In normal immune responses, type I interferons have a critical role in the defence against viruses, yet in many rheumatic diseases ...
Theresa Wampler Muskardin, Timothy B. Niewold   +1 more
exaly   +3 more sources

Type I interferons in infectious disease [PDF]

Nature Reviews Immunology, 2015
Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses.
Andreas Wack, Alan Sher, Anne O'Garra
exaly   +4 more sources

Type I Interferons

International Reviews of Immunology, 1998
Type I interferons (IFNs) constitute a family of structurally related proteins that are all derived from the same ancestral gene and act on a common cell-surface receptor. Contrary to many other cytokines, the production of type I IFNs is not a specialized function, and all cells in the organism can produce them, usually as a result of induction by ...
E, De Maeyer, J, De Maeyer-Guignard
openaire   +2 more sources

Type I Interferons in Autoimmune Disease

Annual Review of Pathology: Mechanisms of Disease, 2019
Type I interferons, which make up the first cytokine family to be described and are the essential mediators of antivirus host defense, have emerged as central elements in the immunopathology of systemic autoimmune diseases, with systemic lupus erythematosus as the prototype.
Mary K Crow, Kyriakos A Kirou, Mikhail Olferiev   +2 more
exaly   +3 more sources

Type I interferon and lupus

Current Opinion in Rheumatology, 2009
Patients with lupus have signs of an ongoing production of type I interferons (IFNs) that are of importance both for the etiopathogenesis and the clinical manifestations. In this review, we summarize the latest information concerning the type I IFN system in lupus.Activated plasmacytoid dendritic cells are responsible for the IFNalpha production in ...
Lars, Rönnblom, Gunnar V, Alm, Maija-Leena, Eloranta   +2 more
openaire   +2 more sources

Regulation of type I interferon responses [PDF]

Nature Reviews Immunology, 2013
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs).
Laura Donlin, Lionel B Ivashkiv
exaly   +3 more sources