Results 251 to 260 of about 521,269 (357)

Reviewer #1 (Public Review): Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

Jianwen Chen, Bao Zhao, Hong Dong, Tianliang Li, Xiang Cheng, Wang Gong, Jing Wang, Junran Zhang, Gang Xin, Yanbao Yu, Yu L Lei, Jennifer D Black, Zihai Li, Haitao Wen   +13 more
openalex   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

TOR3A represses type I interferon production and limits viral clearance during respiratory syncytial virus infection. [PDF]

Emerg Microbes Infect
Li X, Chen Z, Wu M, Zhu P, Qiao G, Li J, Ye Y, Cai J, Zhou Y, Dai X, Wang Y, Li C, Huang J, Zhou J, Xu F, Tan C, Shao Y, Gao X, Hu J, Xu X, Dong C, Hao C, Yang Y, Zhang J.   +23 more
europepmc   +1 more source

Type I interferon and receptor activator ofnuclear factor Kappa B signaling withinthe central nervous system

, 2016
Reza Khorooshi, Ruthe Dieu, Marie-Louise Hyre Arpe, Oriane Cédile, Marlene Mørch, Stefan Lienenklaus, Trevor Owens   +6 more
openalex   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Type I interferon signaling is required for resistance to primary influenza virus infection and vaccine-induced long-term immunity. [PDF]

J Virol
Kim K-H, Hwang HS, Pal SS, Tien Le CT, Grovenstein P, Yeasmin M, Song JM, Kwon Y-M, Wang B, Kang S-M.   +9 more
europepmc   +1 more source

407 Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint therapy [PDF]

C. Martins, Julia Holzgruber, Zsolt Kulcsár, Alexandra Duplaine, E. Rasbach, Katia Boniface, Julien Sénéschal, Wolfram Hoetzenecker, S.R. Barthel, Tobias Schatton   +9 more
openalex   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Type I-interferon β induces a strong anti-tumour response in bladder cancer cells. [PDF]

J Cancer Res Clin Oncol
Hesse M, Iltzsche M, Nahhas D, Thomas C, Füssel S, Kind B.   +5 more
europepmc   +1 more source