Results 191 to 200 of about 1,669,550 (354)

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.

Cell Host and Microbe, 2016
A. Grant, S. S. Ponia, Shashank Tripathi, V. Balasubramaniam, Lisa Miorin, M. Sourisseau, Megan C Schwarz, M. Sánchez-Seco, M. Evans, S. Best, A. García-Sastre   +10 more
semanticscholar   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Aging Reshapes γ/δ T-Cell Immunity Through a Type I Interferon-Foxo1 Axis. [PDF]

Aging Cell
Durand A, Porte S, Xing E, Wu C, Le Bon A, Auffray C, Lucas B, Martin B.   +7 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Age- and Sex-Dependent Variation in the Type I Interferon Signature of Healthy Individuals. [PDF]

Medicina (Kaunas)
Galliano I, Volpe M, Calvi C, Pavan M, Massobrio A, Gambarino S, Albiani R, Linari C, Clemente A, Pau A, Montanari P, Bergallo M.   +11 more
europepmc   +1 more source

Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages [PDF]

Rodrigo Díaz‐Pino, Gillian Rice, Diego San Felipe, Tamar Pepanashvili, Paul R. Kasher, Tracy A. Briggs, Gloria López‐Castejón   +6 more
openalex   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

SARS-CoV-2 promote autophagy to suppress type I interferon response

Signal Transduction and Targeted Therapy, 2021
Xianfeng Hui, Linliang Zhang, Lei Cao, Kun Huang, Ya Zhao, Yufei Zhang, Xi Chen, Xian Lin, Mingzhou Chen, Meilin Jin   +9 more
doaj   +1 more source

Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9 [PDF]

, 2008
Nina Gratz, María Siller, Barbara Schaljo, Zaid Ahmed Pirzada, Irene Gattermeier, Ivo Vojtek, Carsten J. Kirschning, Hermann Wagner, Shizuo Akira, Emmanuelle Charpentier, Pavel Kovarik   +10 more
openalex   +1 more source

Regulatory effects of chicken TRIM25 on the replication of ALV-A and the MDA5-mediated type I interferon response [PDF]

, 2020
Jinrun Zhou, Junhong Liu, Hongmei Li, Yue Zhao, Ziqiang Cheng, Yan-meng Hou, Huijun Guo   +6 more
openalex   +1 more source