Results 301 to 310 of about 1,669,550 (354)
The gut microbiota limits systemic inflammation during neurotrophic viral CNS infection by priming tonic type I interferon signaling. [PDF]
J NeuroinflammationCho HW +6 more
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SHP-1 Promotes the Replication of Porcine Epidemic Diarrhea Virus by Inhibiting TRAF3-Mediated Type I Interferon Immune Responses. [PDF]
PathogensHu J, Kong Y, Liu Y, Li N, Jiang S.
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Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice. [PDF]
Nat CommunKigar SL +14 more
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Type I Interferons in Autoimmunity
Journal of Investigative Dermatology, 2022Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies ...
Ruth Fernandez-Ruiz, Timothy B. Niewold
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International Reviews of Immunology, 1998
Type I interferons (IFNs) constitute a family of structurally related proteins that are all derived from the same ancestral gene and act on a common cell-surface receptor. Contrary to many other cytokines, the production of type I IFNs is not a specialized function, and all cells in the organism can produce them, usually as a result of induction by ...
E, De Maeyer, J, De Maeyer-Guignard
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Type I interferons (IFNs) constitute a family of structurally related proteins that are all derived from the same ancestral gene and act on a common cell-surface receptor. Contrary to many other cytokines, the production of type I IFNs is not a specialized function, and all cells in the organism can produce them, usually as a result of induction by ...
E, De Maeyer, J, De Maeyer-Guignard
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Current Opinion in Rheumatology, 2009
Patients with lupus have signs of an ongoing production of type I interferons (IFNs) that are of importance both for the etiopathogenesis and the clinical manifestations. In this review, we summarize the latest information concerning the type I IFN system in lupus.Activated plasmacytoid dendritic cells are responsible for the IFNalpha production in ...
Lars, Rönnblom +2 more
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Patients with lupus have signs of an ongoing production of type I interferons (IFNs) that are of importance both for the etiopathogenesis and the clinical manifestations. In this review, we summarize the latest information concerning the type I IFN system in lupus.Activated plasmacytoid dendritic cells are responsible for the IFNalpha production in ...
Lars, Rönnblom +2 more
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Type I and Type II Interferon Receptors
Journal of Interferon Research, 1984Binding site competition studies of 125I-interferon (IFN)-gamma were performed with homogeneous preparations of IFNs alpha 2, beta, and gamma. It was found that only IFN-gamma could compete for the specific binding site of 125I-IFN-gamma in both WISH and FS11 cells.
P, Orchansky +3 more
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Type I interferon genes and proteins
Biotherapy, 1996The large number of type I interferon genes in mammalian species could be explained by simple redundancy, by different functions for different interferons, or by different spatial or temporal patterns of expression. Different functions would require different receptors for each interferon, while different patterns of expression would require different ...
M O, Díaz, D, Testa
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