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Type I interferons: expression and signalization
Cellular and Molecular Life Sciences CMLS, 1998Type I interferon (IFN-A and IFN-B) genes encode a large family of multifunctional secreted proteins involved in antiviral defence, cell growth regulation and immune activation. These cytokines, as a consequence of their biological activities, have been established as effective therapeutic molecules for malignant and viral diseases.
J, Doly, A, Civas, S, Navarro, G, Uze
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Type I interferons in anticancer immunity
Nature Reviews Immunology, 2015Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this Review, we discuss accumulating evidence indicating that type I IFNs produced by malignant cells or tumour-infiltrating dendritic cells also control the autocrine or paracrine circuits that underlie cancer immunosurveillance.
Zitvogel, Laurence +4 more
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Fine tuning type I interferon responses
Cytokine & Growth Factor Reviews, 2013Interferon responses are balanced between protection against pathogens and other disease agents versus toxicity and development of chronic diseases. Optimal outcomes are achieved by regulating the nature, strength and duration of Interferon (IFN) production, IFN-receptor interaction and signalling pathways modulated in a manner appropriate for ...
Paul J, Hertzog, Bryan R G, Williams
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Virologie (Montrouge, France)
Type I interferons (IFNa/b) form a family of related cytokines that include INFa, b, e/s, j, x (human) and limitin (mouse). These cytokines exert a potent antiviral activity, control cell proliferation and modulate the immune response. They are used in the fight against viral infections, tumors, and multiple sclerosis.
S, Delhaye +4 more
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Type I interferons (IFNa/b) form a family of related cytokines that include INFa, b, e/s, j, x (human) and limitin (mouse). These cytokines exert a potent antiviral activity, control cell proliferation and modulate the immune response. They are used in the fight against viral infections, tumors, and multiple sclerosis.
S, Delhaye +4 more
openaire +1 more source
Structure-activity of type I interferons
Biotherapy, 1997Type I IFNs constitute a family of proteins exhibiting high homology in primary, secondary, and tertiary structures. They interact with the same receptor and transmit signals to cellular nucleus through a similar mechanism, eliciting roughly homogeneous biological activity.
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Science's STKE, 2003
The type I interferon (IFN-α/β) signal transduction pathway is not only the first-characterized Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, but one of the best studied in molecular detail. IFN-α-stimulated gene factor 3 (ISGF3) is atypical for STAT-containing complexes, because it requires interaction with an ...
D. S. Aaronson, C. M. Horvath
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The type I interferon (IFN-α/β) signal transduction pathway is not only the first-characterized Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, but one of the best studied in molecular detail. IFN-α-stimulated gene factor 3 (ISGF3) is atypical for STAT-containing complexes, because it requires interaction with an ...
D. S. Aaronson, C. M. Horvath
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Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation
Immunity, 2022Kelly M Cautivo +2 more
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Type I Interferons and Receptors
20101 Purification of Human Leukocyte Interferon α 2 Purification of Human Fibroblast Interferon-β 3 Activities of the Purified IFN-α Species 4 Functional Unit of IFN-α 5 Recombinant Human IFN-β 6 Interferon Receptors 7 The type II Interferon (IFN-γ) Receptor 8 The type I Interferon (IFN-α/β/ω) Receptor 9 The Cytokine type ...
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Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop
Science, 2021Lu Bai, Margaux Vienne, Ling Tang
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