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Autonomous STING signaling in Purkinje cells drives neurodegeneration independent of type I interferon. [PDF]

Cell Rep
Yang K, Dunn M, Torres-Ramirez G, Dobbs N, Shakkottai VG, Yan N.   +5 more
europepmc   +1 more source

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Type I Interferons in Autoimmunity

Journal of Investigative Dermatology, 2022
Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies ...
Ruth Fernandez-Ruiz, Timothy B. Niewold
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Type I Interferons

International Reviews of Immunology, 1998
Type I interferons (IFNs) constitute a family of structurally related proteins that are all derived from the same ancestral gene and act on a common cell-surface receptor. Contrary to many other cytokines, the production of type I IFNs is not a specialized function, and all cells in the organism can produce them, usually as a result of induction by ...
E, De Maeyer, J, De Maeyer-Guignard
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Type I interferon and lupus

Current Opinion in Rheumatology, 2009
Patients with lupus have signs of an ongoing production of type I interferons (IFNs) that are of importance both for the etiopathogenesis and the clinical manifestations. In this review, we summarize the latest information concerning the type I IFN system in lupus.Activated plasmacytoid dendritic cells are responsible for the IFNalpha production in ...
Lars, Rönnblom, Gunnar V, Alm, Maija-Leena, Eloranta   +2 more
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Type I and Type II Interferon Receptors

Journal of Interferon Research, 1984
Binding site competition studies of 125I-interferon (IFN)-gamma were performed with homogeneous preparations of IFNs alpha 2, beta, and gamma. It was found that only IFN-gamma could compete for the specific binding site of 125I-IFN-gamma in both WISH and FS11 cells.
P, Orchansky, D, Novick, D G, Fischer, M, Rubinstein   +3 more
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Type I interferon genes and proteins

Biotherapy, 1996
The large number of type I interferon genes in mammalian species could be explained by simple redundancy, by different functions for different interferons, or by different spatial or temporal patterns of expression. Different functions would require different receptors for each interferon, while different patterns of expression would require different ...
M O, Díaz, D, Testa
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Type I-interferon signalling in fish

Fish & Shellfish Immunology, 2002
Type I interferon (IFN) signalling uses a dual mechanism of action. A Jak-Stat pathway extensively described in mammals involves a cascade of reactions from the interaction of the IFN molecule with its membrane receptor to the stimulation of IFN-induced gene promoters leading in turn to an antiviral state. Regulation of IFN activity is also mediated by
Bertrand, Collet, Christopher J, Secombes   +1 more
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Measurement of Type I Interferon Production

Current Protocols in Immunology, 2011
AbstractThe Basic Protocol in this unit describes measurement of murine interferon (IFN)α/β by intracellular staining for these cytokines and detection by flow cytometry. Alternate protocols detail an enzyme‐linked immunoabsorbent assay (ELISA) for IFNα and a biological assay to measure IFN.
Rosalind E, Seeds, Joanna L, Miller
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Type I Interferons in Autoimmune Disease

Annual Review of Pathology: Mechanisms of Disease, 2019
Type I interferons, which make up the first cytokine family to be described and are the essential mediators of antivirus host defense, have emerged as central elements in the immunopathology of systemic autoimmune diseases, with systemic lupus erythematosus as the prototype.
Mary K, Crow, Mikhail, Olferiev, Kyriakos A, Kirou   +2 more
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Type I interferonopathies: Mendelian type I interferon up-regulation

Current Opinion in Immunology, 2015
The concept of grouping Mendelian disorders associated with an up-regulation of type I interferon has only recently been suggested. Here we discuss the progress being made in the delineation and understanding of this novel set of inborn errors of immunity, the human type I interferonopathies.
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