Signal Transduction by Type I Interferons [PDF]
BioTechniques, 2002 The two classes of interferons, type I (IFNalpha, IFNbeta, IFNomega, and IFNtau) and type II (IFNgamma) are pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on their target cells. This article summarizes the advances made in elucidating the molecular events that mediate the biological responses to type I ...
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Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses [PDF]
Science, 2013 Interfering with Interferons Infections with Mycobacteria, including Mycobacterium leprae or M. tuberculosis , vary substantially in their clinical presentation. For instance, in some cases of M. leprae
Rosane M B, Teles +19 more
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Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 [PDF]
, 2011 The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of viruses replicating in the cytoplasm of eukayotes have evolved 2'-O-methyltransferases to modify autonomously their mRNAs.
A Ghosh +55 more
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Adjuvant activity of type I interferons
bchm, 2008 AbstractType I interferons (IFNs) produced primarily by plasmacytoid dendritic cells (pDCs) as part of the innate immune response to infectious agents induce the maturation of myeloid DCs and enhance antigen presentation. Type I IFNs also enhance apoptosis of virus-infected cells, stimulate cross priming and enhanced presentation of viral peptides ...
Tovey, M. G. +2 more
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A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection [PDF]
, 2012 The innate immune response provides the first line of defense against viruses and other pathogens by responding to specific microbial molecules. Influenza A virus (IAV) produces double-stranded RNA as an intermediate during the replication life cycle ...
Maelfait, Jonathan +8 more
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Assessment of Type I Interferon Signaling in Pediatric Inflammatory Disease [PDF]
, 2017 International audiencePURPOSE: Increased type I interferon is considered relevant to the pathology of a number of monogenic and complex disorders spanning pediatric rheumatology, neurology, and dermatology.
A Brehm +55 more
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Opposing roles for interferon regulatory factor-3 (IRF-3) and type I interferon signaling during plague. [PDF]
PLoS Pathogens, 2012 Type I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of host cells.
Ami A Patel +4 more
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Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2. [PDF]
, 2016 The type I interferon (IFN) response is a crucial innate immune signalling pathway required for defense against viral infection. Accordingly, the great majority of mammalian viruses possess means to inhibit this important host immune response.
Lu, Y +4 more
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Complexities of Type I Interferon Biology: Lessons from LCMV
Viruses, 2019 Over the past decades, infection of mice with lymphocytic choriomeningitis virus (LCMV) has provided an invaluable insight into our understanding of immune responses to viruses.
Tamara Suprunenko, Markus J. Hofer
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Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons [PDF]
, 2020 BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Bräuer, Anja U. +7 more
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