Results 81 to 90 of about 26,674,548 (252)
Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands [PDF]
, 1992 Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a ...
Pavic, Ivica +5 more
core +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Opposing roles for interferon regulatory factor-3 (IRF-3) and type I interferon signaling during plague. [PDF]
PLoS Pathogens, 2012 Type I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of host cells.
Ami A Patel +4 more
doaj +1 more source
Transcriptional responses of tumor cell lines to interferon-alpha [PDF]
, 2013 Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core +1 more source
The Dual Nature of Type I and Type II Interferons [PDF]
Frontiers in Immunology, 2018 Type I and type II interferons (IFN) are central to both combating virus infection and modulating the antiviral immune response. Indeed, an absence of either the receptor for type I IFNs or IFN-y have resulted in increased susceptibility to virus infection, including increased virus replication and reduced survival.
Amanda J. Lee, Ali A. Ashkar
openaire +3 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The transient nature of bunyamwera orthobunyavirus NSs protein expression : effects of increased stability of NSs protein on virus replication [PDF]
, 2013 The NSs proteins of bunyaviruses are the viral interferon antagonists, counteracting the host's antiviral response to infection. During high-multiplicity infection of cultured mammalian cells with Bunyamwera orthobunyavirus (BUNV), NSs is rapidly ...
Fragkoudis, R. +8 more
core +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
The role of PML proteins in adenovirus type 5 infection and the type I interferon response [PDF]
Promyelocytic leukaemia (PML) proteins consist of a collection of related isoforms that are the nucleating components of sub-nuclear structures termed PML nuclear bodies (PML NBs). Numerous functions are attributed to PML and PML NBs, including a role
Wright, Jordan
core
Type I Interferon in the Pathogenesis of Lupus [PDF]
The Journal of Immunology, 2014 Abstract Investigations of patients with systemic lupus erythematosus have applied insights from studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator, as central to the pathogenesis of this prototype systemic autoimmune disease. Genetic association data identify regulators of nucleic acid degradation
openaire +2 more sources