Results 81 to 90 of about 1,876,058 (400)

Assessment of Type I Interferon Signaling in Pediatric Inflammatory Disease [PDF]

, 2017
International audiencePURPOSE: Increased type I interferon is considered relevant to the pathology of a number of monogenic and complex disorders spanning pediatric rheumatology, neurology, and dermatology.
A Brehm, AL Mathieu, Alexandre Belot, Anthony Oojageer, Brigitte Bader-Meunier, CD Conrad, Christine Bodemer, D Tonduti, DM Santer, E Lausch, EC Baechler, EC Baechler, F Allantaz, F Goutieres, GI Rice, GI Rice, GI Rice, GI Rice, Gillian I. Rice, Isabelle Melki, J Hua, JH Livingston, L Bennett, M Berger Rentsch, M Henneke, MA Jang, Marie-Louise Frémond, Mathieu P. Rodero, ME Meuwissen, MP Rodero, Naoki Kitabayashi, P Lebon, P Navon Elkan, P Quartier, P Starokadomskyy, Pierre Quartier, PK Chakraborty, Q Zhou, R Banchereau, S Oon, SA Greenberg, SC Eckard, SM Al-Mayouf, TA Briggs, TB Niewold, Tracy A. Briggs, V Sisirak, X Zhang, Y Li, Y Liu, Yanick J. Crow, YJ Crow, YJ Crow, YJ Crow, YJ Crow, YJ Seo   +55 more
core   +3 more sources

A diverse array of gene products are effectors of the type I interferon antiviral response

Nature, 2011
The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs).
J. Schoggins, Sam J. Wilson, M. Panis, Mary Y. Murphy, Christopher T. Jones, P. Bieniasz, C. Rice   +6 more
semanticscholar   +1 more source

Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway

Nature Communications, 2021
Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils and monocytes with potent immune suppressive activity. These cells play an important role in accelerating tumor progression and undermining the efficacy of anti-cancer ...
Kevin Alicea-Torres, E. Sanseviero, J. Gui, Jinyun Chen, F. Veglia, Qiujing Yu, Laxminarasimha Donthireddy, A. Kossenkov, Cindy Lin, Shuyu Fu, Charles Mulligan, Brian Nam, G. Masters, F. Denstman, Joseph Bennett, N. Hockstein, A. Rynda-Apple, Yulia Nefedova, S. Fuchs, D. Gabrilovich   +19 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PD-1 signaling promotes control of chronic viral infection by restricting type-I-interferon-mediated tissue damage [PDF]

, 2019
Immune responses are essential for pathogen elimination but also cause tissue damage, leading to disease or death. However, it is unclear how the host immune system balances control of infection and protection from the collateral tissue damage.
Egawa, Takeshi, Raju, Saravanan, Verbaro, Daniel J   +2 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Senegalese sole (Solea senegalensis) ISG15: molecular characterization and in vivo interplay with viral infections [PDF]

, 2015
The interferon-stimulated gene 15 (Isg15) is strongly induced by type I interferon (IFN I), viral infection, and double-stranded RNA (poly I:C) in several fish species, suggesting that Isg15 protein could play a key role in fish innate immunity against ...
Alonso-Sanchez, Maria del Carmen, Bandín, Isabel, Bejar-Alvarado, Julia, García-Rosado, Esther, Podadera, Ana María, Álvarez-Torres, Daniel   +5 more
core  

Dengue and Zika virus cross-reactive human monoclonal antibodies protect against Spondweni virus infection and pathogenesis in mice [PDF]

, 2019
Summary: Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti.
Aliota, Ansarah-Sobrinho, Barba-Spaeth, Cerbino-Neto, Cugola, Culshaw, Dejnirattisai, Dejnirattisai, Dowd, Draper, Driggers, Elong Ngono, Falk, Fernandez, Fox, Goncé, Gorman, Govero, Grant, Haddow, Haddow, Halstead, Hasan, Hessell, Jagger, Kokernot, Lanciotti, Lazear, Ma, MacNamara, Mansuy, Mansuy, Mansuy, McDonald, Miner, Morrison, Morrison, Mukherjee, Nguyen, Oliphant, Pal, Pierson, Pierson, Platt, Richner, Rossi, Rouvinski, Sapparapu, Sheehan, Suy, Taraphdar, White, Zhao   +52 more
core   +3 more sources

Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis

Clinical Microbiology Reviews, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million COVID-19-positive cases and a mortality rate of about 2.2%, as of 10 December 2020. In
Santhamani Ramasamy, S. Subbian
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source