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BMC Microbiology, 2003 Background Pseudomonas aeruginosa, an increasingly prevalent opportunistic pathogen, utilizes a type III secretion system for injection of toxins into host cells in order to initiate infection.
Chabert Jacqueline +7 more
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Energy source of flagellar type III secretion [PDF]
Nature, 2008 Bacterial flagella contain a specialized secretion apparatus that functions to deliver the protein subunits that form the filament and other structures to outside the membrane. This apparatus is related to the injectisome used by many gram-negative pathogens and symbionts to transfer effector proteins into host cells; in both systems this export ...
Koushik, Paul +4 more
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mBio, 2018 Nonflagellar type III secretion systems (nf T3SSs) form a cell surface needle-like structure and an associated translocon that deliver bacterial effector proteins into eukaryotic host cells.
Xiu-Jun Yu +4 more
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Expression and Quorum Sensing Regulation of Type III Secretion System Genes of Vibrio harveyi during Infection of Gnotobiotic Brine Shrimp. [PDF]
PLoS ONE, 2015 Type III secretion systems enable pathogens to inject their virulence factors directly into the cytoplasm of the host cells. The type III secretion system of Vibrio harveyi, a major pathogen of aquatic organisms and a model species in quorum sensing ...
H A Darshanee Ruwandeepika +3 more
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Yersiniatype III secretion [PDF]
The Journal of Cell Biology, 2002 Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block the cells' response to infection.
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Regulation of type III secretion in Bordetella [PDF]
Molecular Microbiology, 2004 SummaryThe BvgAS virulence control system regulates the expression of type III secretion genes in Bordetella subspecies that infect humans and other mammals. We have identified five open reading frames, btrS, btrU, btrX, btrW and btrV, that are activated by BvgAS and encode regulatory factors that control type III secretion at the levels of ...
Seema, Mattoo +3 more
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Natural Product Type III Secretion System Inhibitors
Antibiotics, 2019 Many known inhibitors of the bacterial type III secretion system (T3SS), a virulence factor used by pathogenic bacteria to infect host cells, are natural products.
Heather A. Pendergrass, Aaron E. May
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A Helical Transport Mechanism for Type III Secretion [PDF]
Biophysical Journal, 2015 Gram-negative pathogenic bacteria, like Salmonella typhimurium and Shigella flexneri, employ the Type III Secretion System (T3SS) to infect human cells. The T3SS is a large protein secretion channel that assembles to span a ∼50nm gap between the bacterial and target cell walls. A key component of the S.
Gupta, R. +5 more
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Genetics and Molecular Biology, 2005 The secretion of bacterial virulence factors and flagellar components requires the assistance of specific type III and flagellar chaperones. Standard computational annotation of the genome of Xanthomonas axonopodis pv citri, a plant pathogen that causes ...
Letícia Khater +5 more
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The Pseudomonas syringae avrRpt2 Gene Contributes to Virulence on Tomato
Molecular Plant-Microbe Interactions, 2005 In order to cause disease on plants, gram-negative phytopathogenic bacteria introduce numerous virulence factors into the host cell in order to render host tissue more hospitable for pathogen proliferation.
Melisa T. S. Lim, Barbara N. Kunkel
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