Results 1 to 10 of about 1,657,824 (211)

In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host

Nature Communications, 2021
Bordetella hinzii is an emerging pathogen with zoonotic risk to humans, known to be able to cause respiratory tract infection, bacteremia and endocarditis.
A. Launay, C.-J. Wu, A. Dulanto Chiang, J.-H. Youn, P. P. Khil, J. P. Dekker   +5 more
doaj   +1 more source

Transcription Inhibitors with XRE DNA-Binding and Cupin Signal-Sensing Domains Drive Metabolic Diversification in Pseudomonas

mSystems, 2021
Transcription factors (TFs) are instrumental in the bacterial response to new environmental conditions. They can act as direct signal sensors and subsequently induce changes in gene expression leading to physiological adaptation.
Julian Trouillon, Michel Ragno, Victor Simon, Ina Attrée, Sylvie Elsen   +4 more
doaj   +1 more source

Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group

Nature Communications, 2023
Three types of DNA methyl modifications have been detected in bacterial genomes, and mechanistic studies have demonstrated roles for DNA methylation in physiological functions ranging from phage defense to transcriptional control of virulence and host ...
Michael J. Tisza, Derek D. N. Smith, Andrew E. Clark, Jung-Ho Youn, NISC Comparative Sequencing Program, Pavel P. Khil, John P. Dekker   +6 more
doaj   +1 more source

Integrative DNA methylome and transcriptome analysis reveals DNA adenine methylation is involved in Salmonella enterica Typhimurium response to oxidative stress

Microbiology Spectrum, 2023
Salmonella could survive and replicate in macrophages, where it encounters multiple stresses. Deficiency of a DNA adenine methyltransferase impairs the survival of Salmonella enterica serovar Typhimurium (S. Typhimurium) in hydrogen peroxide.
Wenting Zhang, Lin Lyu, Zhihiong Xu, Jinjing Ni, Danni Wang, Jie Lu, Yu-Feng Yao   +6 more
doaj   +1 more source

Dual role of CsrA in regulating the hemolytic activity of Escherichia coli O157:H7

Virulence, 2022
Post-transcriptional global carbon storage regulator A (CsrA) is a sequence-specific RNA-binding protein involved in the regulation of multiple bacterial processes. Hemolysin is an important virulence factor in the enterohemorrhagic Escherichia coli O157:
Zhibin Sun, Ning Zhou, Wenting Zhang, Yan Xu, Yu-Feng Yao   +4 more
doaj   +1 more source

Understanding the pathogenesis of infectious diseases by single-cell RNA sequencing

Microbial Cell, 2021
Infections are highly orchestrated and dynamic processes, which involve both pathogen and host. Transcriptional profiling at the single-cell level enables the analysis of cell diversity, heterogeneity of the immune response, and detailed molecular ...
Wanqiu Huang, Danni Wang, Yu-Feng Yao
doaj   +1 more source

PaP1, a Broad-Spectrum Lysin-Derived Cationic Peptide to Treat Polymicrobial Skin Infections

Frontiers in Microbiology, 2022
Most skin infections, including those complicating burns, are polymicrobial involving multiple causative bacteria. Add to this the fact that many of these organisms may be antibiotic-resistant, and a simple skin lesion or burn could soon become life ...
Ryan D. Heselpoth, Chad W. Euler, Chad W. Euler, Chad W. Euler, Vincent A. Fischetti   +4 more
doaj   +1 more source

Streptococcus pneumoniae utilizes a novel dynamin independent pathway for entry and persistence in brain endothelium

Current Research in Microbial Sciences, 2020
Adoption of an endocytosis route promoting safe intracellular trafficking is a pre-requisite for development of invasive diseases by Streptococcus pneumoniae (SPN).
Manalee V. Surve, Shruti Apte, Smita Bhutda, Kshama G. Kamath, Kwang S. Kim, Anirban Banerjee   +5 more
doaj   +1 more source

Activity Assays for Bacteriophage Endolysin PlyPy

Bio-Protocol, 2014
Bacterial viruses (bacteriophages) escape and kill their host by degrading the bacterial peptidoglycan layer through the mechanism of enzymes called endolysins: peptidoglycan degrading enzymes.
Rolf Lood, Vincent Fischetti
doaj   +1 more source

Gene essentiality profiling reveals a novel determinant of stresses preventing protein aggregation in Salmonella

Emerging Microbes and Infections, 2022
Adaptation to various stresses during infection is important for Salmonella Typhimurium virulence, while the fitness determinants under infection-relevant stress conditions remain unknown.
Zuoqiang Wang, Siqi Zhu, Congcong Li, Lin Lyu, Jingchen Yu, Danni Wang, Zhihong Xu, Jinjing Ni, Beile Gao, Jie Lu, Yu-Feng Yao   +10 more
doaj   +1 more source