Results 41 to 50 of about 1,657,824 (211)

Second-generation lysocins as therapeutics for treating Pseudomonas aeruginosa infections

Antimicrobial Agents and Chemotherapy
Pseudomonas aeruginosa is a leading cause of nosocomial infections, including pneumonia and urinary tract infections, and the primary cause of morbidity and mortality in cystic fibrosis patients.
Ryan D. Heselpoth, Chad W. Euler, Vincent A. Fischetti   +2 more
doaj   +1 more source

Analysis of novel meningococcal vaccine formulations

Human Vaccines & Immunotherapeutics, 2017
The protective effect of meningococcal vaccines targeting disease causing serogroups exemplified by the introduction of MenAfriVac™ in Africa, is well established and documented in large population-based studies.
Susu M. Zughaier
doaj   +1 more source

Strain-specific variation in the complement resistome of Pseudomonas aeruginosa

Infection and Immunity
Bloodstream infections caused by Pseudomonas aeruginosa are associated with high mortality rates. The complement system, a key component of the innate immune response, plays a major role in eliminating P. aeruginosa from human blood.
Manon Janet-Maitre, Mylène Robert-Genthon, François Cretin, Sylvie Elsen, Ina Attrée   +4 more
doaj   +1 more source

Pathogenesis of Fungal and Bacterial Microbes [PDF]

Pathogens, 2020
The pathogenesis of fungal and bacterial microbes is a complex process involving distinct parameters, including virulence factors, nutrient sensing and availability, microbial signals, as well as host status and defense responses. Defining pathogenesis improves our understanding of how an organism causes diseases and provides insight into novel ...
openaire   +3 more sources

Identification of a Neisseria gonorrhoeae Histone Deacetylase: Epigenetic Impact on Host Gene Expression

Pathogens, 2020
Epigenetic reprogramming in macrophages is termed trained innate immunity, which regulates immune tolerance and limits tissue damage during infection. Neisseria gonorrhoeae is a strict human pathogen that causes the sexually transmitted infection termed ...
Susu M. Zughaier, Corinne E. Rouquette-Loughlin, William M. Shafer   +2 more
doaj   +1 more source

Methylation of PhoP by CheR Regulates Salmonella Virulence

mBio, 2021
Posttranslational modifications (PTMs) play an important role in regulating enzyme activities, protein-protein interactions, or DNA-protein recognition and, consequently, modulate many biological functions.
Yang Su, Jianhui Li, Wenting Zhang, Jinjing Ni, Rui Huang, Zuoqiang Wang, Sen Cheng, Yue Wang, Zhixin Tian, Qiuxiang Zhou, Donghai Lin, Wenjuan Wu, Christoph M. Tang, Xiaoyun Liu, Jie Lu, Yu-Feng Yao   +15 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Isolation and Purification of Mycobacterial Extracellular Vesicles

, 2023
Bacterial extracellular vesicles (EVs) contain numerous active substances that mediate bacterial interactions with their host and with other microbes. Best defined are the EVs from Gram-negative bacteria that have been shown to deliver virulence factors,
Umashankar Rao, Komal, Godaly, Gabriela, Umashankar Rao, Komal,, Lund University., Godaly, Gabriela,   +4 more
core   +2 more sources

Dietary L-arabinose-induced gut dysbiosis exacerbates Salmonella infection outcome

mSystems
The gut microbiota is essential for providing colonization resistance against pathogens. Dietary sugars markedly shift the composition of the intestinal microbiota and alter host susceptibility to enteric infections.
Jingchen Yu, Huang Tang, Ning Zhou, Zuoqiang Wang, Wanqiu Huang, Yana Chen, Danni Wang, Jinjing Ni, Jie Lu, Yu-Feng Yao   +9 more
doaj   +1 more source