Results 51 to 60 of about 1,657,824 (211)

Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon

mBio, 2017
The MtrCDE efflux pump of Neisseria gonorrhoeae contributes to gonococcal resistance to a number of antibiotics used previously or currently in treatment of gonorrhea, as well as to host-derived antimicrobials that participate in innate defense ...
Corinne E. Rouquette-Loughlin, Yaramah M. Zalucki, Vijaya L. Dhulipala, Jacqueline T. Balthazar, Raúl G. Doyle, Robert A. Nicholas, Afrin A. Begum, Erica L. Raterman, Ann E. Jerse, William M. Shafer   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Preparation and Analysis of Crude Autolytic Enzyme Extracts from Staphylococcus aureus

Bio-Protocol, 2015
The metabolism of the cell surface during bacterial cell division involves synthesis and degradation of peptidoglycan (PGN), the major component of the bacterial cell wall.
Filipa Vaz, Sérgio Filipe
doaj   +1 more source

Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection

Virulence, 2021
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an emerging zoonotic pathogen of canine origin that causes an array of fatal diseases, including bacteremia and endocarditis.
Dorothea Bünsow, Eshraq Tantawy, Tjorven Ostermeier, Heike Bähre, Annette Garbe, Jesper Larsen, Volker Winstel   +6 more
doaj   +1 more source

Localization-Triggered Bacterial Pathogenesis [PDF]

Future Microbiology, 2015
Bacterial infections are becoming an increasing problem worldwide and there is a need for a deeper understanding of how bacteria turn pathogenic. Here, we suggest that one answer may be found by taking into account the localization of the bacteria, both at an anatomical level and at a microenvironment level.
Lood, Rolf, Wollein Waldetoft, Kristofer, Nordenfelt, Pontus   +2 more
openaire   +3 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Exolysin Shapes the Virulence of Pseudomonas aeruginosa Clonal Outliers

Toxins, 2017
Bacterial toxins are important weapons of toxicogenic pathogens. Depending on their origin, structure and targets, they show diverse mechanisms of action and effects on eukaryotic cells.
Emeline Reboud, Pauline Basso, Antoine P. Maillard, Philippe Huber, Ina Attrée   +4 more
doaj   +1 more source

Genotype diversity of brucellosis agents isolated from humans and animals in Greece based on whole-genome sequencing

BMC Infectious Diseases, 2023
Background Brucellosis is a zoonotic disease whose causative agent, Brucella spp., is endemic in many countries of the Mediterranean basin, including Greece.
Hanka Brangsch, Vassilios Sandalakis, Maria Babetsa, Evridiki Boukouvala, Artemisia Ntoula, Eirini Makridaki, Athanasia Christidou, Anna Psaroulaki, Kadir Akar, Sevil Erdenlig Gürbilek, Tariq Jamil, Falk Melzer, Heinrich Neubauer, Gamal Wareth   +13 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Salmonella utilizes L-arabinose to silence virulence gene expression for accelerated pathogen growth within the host

Gut Microbes
Carbon source is an important nutrient for bacteria to sustain growth and often acts as a signal that modulates virulence expression. L-arabinose is produced by plants and plays an important role in regulating the global gene expression of bacteria ...
Jingchen Yu, Huang Tang, Yana Chen, Zuoqiang Wang, Wanqiu Huang, Tao Zhou, Bingjie Wen, Chengyue Wang, Shuang Gu, Jinjing Ni, Jing Tao, Danni Wang, Jie Lu, Qing Xie, Yu-Feng Yao   +14 more
doaj   +1 more source