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<i>Salmonella</i> Type III Secretion System Effectors. [PDF]

Int J Mol Sci
Salmonella is estimated to infect between 200 million and over 1 billion people per year. The exact number is not known, as many cases go unreported. Integral to the pathogenesis of Salmonella, as well as numerous other Gram-negative pathogens, is its type III effectors.
Worley MJ.
europepmc   +3 more sources

Type III secretion à la Chlamydia [PDF]

Trends in Microbiology, 2007
Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-dependent, T3S-mediated chlamydial ...
Peters, Jan M, Wilson, David P, Myers, Garry, Timms, Peter, Bavoil, Patrik M   +4 more
openaire   +3 more sources

Active removal of inhibitory components drives the flagellar type 3 secretion-specificity switch

mBio
Type 3 secretion (T3S) systems assemble bacterial nanomachines, including the flagellum and virulence-associated injectisomes, by exporting distinct classes of substrates in a defined temporal order.
Fabienne F. V. Chevance, Dara Niketic, DingBang Wu, Carl Ty Mellor, David F. Blair, Sherwood R. Casjens, Miki Kinoshita, Keiichi Namba, Tohru Minamino, Kelly T. Hughes   +9 more
doaj   +1 more source

Type III Secretion: More Systems Than You Think

Physiology, 2005
The type III secretion (T3S) pathway allows bacteria to inject effector proteins into the cytosol of target animal or plant cells. T3S systems evolved into seven families that were distributed among Gram-negative bacteria by horizontal gene transfer. There are probably a few hundred effectors interfering with control and signaling in eukaryotic cells ...
Troisfontaines, P., Cornelis, G. R.
openaire   +5 more sources

The Structure and Function of Type III Secretion Systems [PDF]

Microbiology Spectrum, 2016
ABSTRACT Type III secretion systems (T3SSs) afford Gram-negative bacteria an intimate means of altering the biology of their eukaryotic hosts—the direct delivery of effector proteins from the bacterial cytoplasm to that of the eukaryote. This incredible biophysical feat is accomplished by nanosyringe “injectisomes,” which form a conduit ...
Ryan Q, Notti, C Erec, Stebbins
openaire   +2 more sources

Assembly of the bacterial type III secretion machinery [PDF]

FEMS Microbiology Reviews, 2014
Many bacteria that live in contact with eukaryotic hosts, whether as symbionts or as pathogens, have evolved mechanisms that manipulate host cell behaviour to their benefit. One such mechanism, the type III secretion system, is employed by Gram-negative bacterial species to inject effector proteins into host cells.
Diepold, A., Wagner, S.
openaire   +4 more sources

Heterologous Complementation Studies With the YscX and YscY Protein Families Reveals a Specificity for Yersinia pseudotuberculosis Type III Secretion

Frontiers in Cellular and Infection Microbiology, 2018
Type III secretion systems harbored by several Gram-negative bacteria are often used to deliver host-modulating effectors into infected eukaryotic cells. About 20 core proteins are needed for assembly of a secretion apparatus.
Jyoti M. Gurung, Jyoti M. Gurung, Ayad A. A. Amer, Ayad A. A. Amer, Monika K. Francis, Monika K. Francis, Tiago R. D. Costa, Tiago R. D. Costa, Shiyun Chen, Anton V. Zavialov, Matthew S. Francis, Matthew S. Francis   +11 more
doaj   +1 more source

Timing is everything: the regulation of type III secretion [PDF]

Cellular and Molecular Life Sciences, 2009
Type Three Secretion Systems (T3SSs) are essential virulence determinants of many Gram-negative bacteria. The T3SS is an injection device that can transfer bacterial virulence proteins directly into host cells. The apparatus is made up of a basal body that spans both bacterial membranes and an extracellular needle that possesses a channel that is ...
Deane, J, Abrusci, P, Johnson, S, Lea, S
openaire   +2 more sources

A truncated mutation of MucA in Pseudomonas aeruginosa from a bronchiectasis patient affects T3SS expression and inflammasome activation

Acta Biochimica et Biophysica Sinica, 2022
Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic airway infection in bronchiectasis patients and is closely associated with poor prognosis.
Liu Yanan, Du Lin, Zhu Yongzhang, Liu Xuefei, Zhou Ning, Li Congcong, Li Qingtian, He Ping   +7 more
doaj   +1 more source

Bacterial flagella and type III secretion systems [PDF]

FEMS Microbiology Letters, 2001
Certain classes of pathogenic bacteria secrete virulence proteins in a Sec-independent manner, by a mechanism known as type III secretion. The main body of the export apparatus specific for virulence proteins is identified as a needle complex, which has a similar structural organization to flagella. The two structures share several proteins with highly
openaire   +2 more sources