Results 61 to 70 of about 350,762 (160)

Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

Molecules, 2010
A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria.
Mikael Elofsson, Tam M. To, Markus K. Dahlgren, J. Mikael Hillgren   +3 more
doaj   +1 more source

An indirect enzyme-linked immunosorbent assay for rapid and quantitative assessment of Type III virulence phenotypes of Pseudomonas aeruginosa isolates

Annals of Clinical Microbiology and Antimicrobials, 2005
Background The presence of a Type III secretion system in clinical isolates of Pseudomonas aeruginosa is associated with severe disease and poor outcomes in infections caused by this pathogen.
Kar Kalipada, Ledizet Michel, Li Li, Koski Raymond A, Kazmierczak Barbara I   +4 more
doaj   +1 more source

Lactoferrin inhibits E. coli O157:H7 growth and attachment to intestinal epithelial cells

Veterinární Medicína, 2010
Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 strains are associated with haemorraghic colitis and haemolytic uremic syndrome (HUS) in humans. Cattle are a reservoir of E. coli O157:H7. We studied the ability of bovine and human lactoferrin,
M. Atef Yekta, F. Verdonck, W. Van Den Broeck, B.M. Goddeeris, E. Cox, D. Vanrompay   +5 more
doaj   +1 more source

Characterization of the Xanthomonas AvrXv4 Effector, a SUMO Protease Translocated into Plant Cells

Molecular Plant-Microbe Interactions, 2004
Homologs of the Yersinia virulence factor YopJ are found in both animal and plant bacterial pathogens, as well as in plant symbionts. The conservation of this effector family indicates that several pathogens may use YopJ-like proteins to regulate ...
Julie Roden, Leah Eardley, Andrew Hotson, Yajuan Cao, Mary Beth Mudgett   +4 more
doaj   +1 more source

Sequence-Based Prediction of Type III Secreted Proteins

PLoS Pathogens, 2009
The type III secretion system (TTSS) is a key mechanism for host cell interaction used by a variety of bacterial pathogens and symbionts of plants and animals including humans. The TTSS represents a molecular syringe with which the bacteria deliver effector proteins directly into the host cell cytosol.
Arnold, Roland, Brandmaier, Stefan, Kleine, Frederick, Tischler, Patrick, Heinz, Eva, Behrens, Sebastian, Niinikoski, Antti, Mewes, Hans Werner, Horn, Matthias, Rattei, Thomas   +9 more
openaire   +7 more sources

A Phosphorylation Switch on Lon Protease Regulates Bacterial Type III Secretion System in Host

mBio, 2018
Most pathogenic bacteria deliver virulence factors into host cytosol through type III secretion systems (T3SS) to perturb host immune responses. The expression of T3SS is often repressed in rich medium but is specifically induced in the host environment.
Xiaofeng Zhou, Doron Teper, Maxuel O. Andrade, Tong Zhang, Sixue Chen, Wen-Yuan Song, Nian Wang   +6 more
doaj   +1 more source

Identification and Characterization of Putative Translocated Effector Proteins of the Edwardsiella ictaluri Type III Secretion System

mSphere, 2016
Edwardsiella ictaluri, a major pathogen in channel catfish aquaculture, encodes a type III secretion system (T3SS) that is essential for intracellular replication and virulence. Previous work identified three putative T3SS effectors in E.
Lidiya P. Dubytska, Matthew L. Rogge, Ronald L. Thune   +2 more
doaj   +1 more source

Type III Secretion in Root-Colonising Pseudomonas

, 2001
Pseudomonads enter into intimate associations with plants that can result in either plant growth promotion or cell death and disease. Two bacteria that exemplify these different interactions are the plant pathogen Pseudomonas syringae and the plant growth-promoting rhizobacterium (PGPR) P. fluorescens. P.
Preston, G, Bertrand, N, Rainey, P
openaire   +2 more sources

Characterization of Pseudomonas alliivorans strains isolated from Georgia, USA: insights into genomic diversity and pathogenicity in onions

Applied and Environmental Microbiology
Pseudomonas alliivorans is an important emerging pathogen affecting numerous crops. The species is closely related to Pseudomonas viridiflava, with which P. alliivorans strains were often misidentified in the past.
Mei Zhao, Michelle Pena Maclellan, Anuj Lamichhane, Sujan Paudel, Ron Gitaitis, Brian Kvitko, Bhabesh Dutta   +6 more
doaj   +1 more source

Comparison of Galleria mellonella, epithelial cell cytotoxicity, and mouse model of bacteremia to measure Pseudomonas aeruginosa virulence

Infection and Immunity
Considerable effort has focused on identifying alternatives to mouse models in research studies. In the field of bacterial pathogenesis, Galleria mellonella and epithelial cell lines have been widely used for this purpose, but the concordance of these ...
Aliki Valdes, Christopher Axline, Travis J. Kochan, Sophia Nozick, Timothy Ward, Issay Niki, Ethan VanGosen, David Hynes, Julia Nelson, Preeti Garai, Tania Afzal, Daniel Amusin, Sumitra D. Mitra, Timothy L. Turner, William Cheng, Joanne J. Lee, Prarthana Prashanth, Nathan B. Pincus, Jonathan P. Allen, Jake Hauser, Egon A. Ozer, Kelly E. R. Bachta, Cheng-Hsun Chiu, Antonio Oliver, Alan R. Hauser   +24 more
doaj   +1 more source