Results 51 to 60 of about 350,762 (160)

Small-Molecule Inhibitors of the Type III Secretion System

Molecules, 2015
Drug-resistant pathogens have presented increasing challenges to the discovery and development of new antibacterial agents. The type III secretion system (T3SS), existing in bacterial chromosomes or plasmids, is one of the most complicated protein ...
Lingling Gu, Shanshan Zhou, Lanping Zhu, Cuirong Liang, Xin Chen   +4 more
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Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. [PDF]

PLoS ONE, 2012
Pathogenic Yersinia species possess a type III secretion system, which is required for the delivery of effector Yop proteins into target cells during infection.
Andrew S Houppert, Elizabeth Kwiatkowski, Elizabeth M Glass, Kristin L DeBord, Peter M Merritt, Olaf Schneewind, Melanie M Marketon   +6 more
doaj   +1 more source

Animal Models of Type III Secretion System-Mediated Pathogenesis

Pathogens, 2019
The type III secretion system (T3SS) is a conserved virulence factor used by many Gram-negative pathogenic bacteria and has become an important target for anti-virulence drugs.
Julia A. Hotinger, Aaron E. May
doaj   +1 more source

Regulation of Effector Delivery by Type III Secretion Chaperone Proteins in Erwinia amylovora

Frontiers in Microbiology, 2018
Type III secretion (TTS) chaperones are critical for the delivery of many effector proteins from Gram-negative bacterial pathogens into host cells, functioning in the stabilization and hierarchical delivery of the effectors to the type III secretion ...
Luisa F. Castiblanco, Lindsay R. Triplett, George W. Sundin   +2 more
doaj   +1 more source

Insights into the Bacterial Type III Secretion System

International Journal of Bio-Resource and Stress Management, 2022
Bacterial type III secretions system (T3SS) is a membrane embedded needle like macromolecular complex structure present in Gram negative bacteria and mostly found in Yersinia, Salmonella, Shigella, Entero Pathogenic E. coli (EPEC), Entero Haemorrhagic E.
Himasri Das, Chandrani Goswami, Losa Rose, Sophia M Gogoi, Durlav P Bora, Girindra K Saikia   +5 more
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High-Throughput Screening of Type III Secretion Determinants Reveals a Major Chaperone-Independent Pathway

mBio, 2018
Numerous Gram-negative bacterial pathogens utilize type III secretion systems (T3SSs) to inject tens of effector proteins directly into the cytosol of host cells.
Nadja Heinz Ernst, Analise Z. Reeves, Julia E. Ramseyer, Cammie F. Lesser   +3 more
doaj   +1 more source

Harpin of Pseudomonas syringae pv. phaseolicola Harbors a Protein Binding Site

Molecular Plant-Microbe Interactions, 2005
Harpin HrpZ of plant-pathogenic bacterium Pseudomonas syringae elicits a hypersensitive response (HR) in some nonhost plants, but its function in the pathogenesis process is still obscure.
Chun-Mei Li, Minna Haapalainen, Justin Lee, Thorsten Nürnberger, Martin Romantschuk, Suvi Taira   +5 more
doaj   +1 more source

Genetic Organization of the Pantoea stewartii subsp. stewartii hrp Gene Cluster and Sequence Analysis of the hrpA, hrpC, hrpN, and wtsE Operons

Molecular Plant-Microbe Interactions, 2001
The hrp/wts gene cluster of Pantoea stewartii subsp. stewartii is required for pathogenicity on sweet corn and the ability to elicit a hypersensitive response (HR) in tobacco.
Reid D. Frederick, Musharaf Ahmad, Doris R. Majerczak, Angel S. Arroyo-Rodríguez, Shulamit Manulis, David L. Coplin   +5 more
doaj   +1 more source

Exploiting the bacterial type III secretion system of

Current Research in Biotechnology
The Gram-negative bacterium Pseudomonas aeruginosa encodes a Type III Secretion System (T3SS), a molecular syringe that injects bacterially-synthesized effector proteins directly into a target mammalian host cell. While classically studied in the context
Amanda N. Tuckey, Jennifer Clark, Rasha Q. Al-Rahahleh, Aisha H. Siddiqui, Steven A. DeFreitas, Wynand P. Roos, Mike T. Lin, Jonathon P. Audia, Robert W. Sobol   +8 more
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An hrcU-Homologous Gene Mutant of Xanthomonas campestris pv. glycines 8ra That Lost Pathogenicity on the Host Plant but Was Able to Elicit the Hypersensitive Response on Nonhosts

Molecular Plant-Microbe Interactions, 1999
Transposon mutagenesis was used to isolate nonpathogenic mutants of Xanthomonas campestris pv. glycines 8ra, which causes bacterial pustule disease in soybean.
Changsik Oh, Sunggi Heu, Jae-Yong Yoo, Yongsup Cho   +3 more
doaj   +1 more source