Results 81 to 90 of about 1,118,779 (342)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Regulation of Effector Delivery by Type III Secretion Chaperone Proteins in Erwinia amylovora

Frontiers in Microbiology, 2018
Type III secretion (TTS) chaperones are critical for the delivery of many effector proteins from Gram-negative bacterial pathogens into host cells, functioning in the stabilization and hierarchical delivery of the effectors to the type III secretion ...
Luisa F. Castiblanco, Lindsay R. Triplett, George W. Sundin   +2 more
doaj   +1 more source

Identification and characterization of a type III secretion system in Chlamydophila psittaci [PDF]

, 2008
Chlamydiaceae are obligate intracellular Gram-negative bacteria replicating in vacuoles inside eukaryotic cells. It has been proven that most of them possess a type III secretion system (T3SS) allowing them to transfer effector molecules in the host cell.
Beeckman, Delphine Sylvie Anne, Geens, Tom, Timmermans, Jean-Pierre, Van Oostveldt, Patric, Vanrompay, Daisy   +4 more
core   +4 more sources

High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Many bacteria capable of causing disease utilize a nanomachine to inject bacterial proteins into mammalian cells. Those proteins have the capacity to modulate cellular functions for the pathogen’s benefit.
C. Butan, M. Lara-Tejero, Wenwei Li, Jun Liu, J. Galán   +4 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Genome Sequence of Pantoea ananatis Strain AMG 501, a Plant Growth-Promoting Bacterium Isolated from Rice Leaves Grown in Paddies of Southern Spain [PDF]

, 2017
Pantoea ananatis AMG 501 is a plant growth-promoting bacterium isolated from rice leaves. Its genome was estimated at 5,102,640 bp with 4,994 coding sequences, encompassing genes related to the metabolism of carbohydrates, to the synthesis of auxins ...
Hungria, Mariangela, Megías Guijo, Manuel, Megías, Esaú, Ollero Márquez, Francisco Javier, Reis Junior, Fábio Bueno, Ribeiro, Renan Augusto   +5 more
core   +1 more source

Yersinia Type III Secretion System Master Regulator LcrF [PDF]

Journal of Bacteriology, 2016
ABSTRACT Many Gram-negative pathogens express a type III secretion (T3SS) system to enable growth and survival within a host. The three human-pathogenic Yersinia species, Y. pestis , Y. pseudotuberculosis , and Y.
Schwiesow, Leah, Lam, Hanh, Dersch, Petra, Auerbuch, Victoria   +3 more
openaire   +5 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Yersiniae Virulence Factors: Type III Secretion System [PDF]

, 2008
Several Gram-negative pathogenic bacteria have evolved a complex protein secretion system termed the Type Three Secretion System (TTSS) to deliver bacterial effector proteins into host-cells that then modulate host-cellular functions.
Blanco, Jessica
core   +1 more source