Results 101 to 110 of about 26,046,637 (294)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2 [PDF]

, 2012
E. coli O157 carries two genes encoding the effector proteins NleH1 and NleH2 which are 87% identical. Despite the similarity between the proteins, the promoter regions upstream of the genes encoding the effectors are more divergent suggesting that the ...
Mitchell, Tim J, Tim J Mitchell, Tom J Evans, Roe, Andrew J, Wang, Dai, Ashleigh Holmes, Ashleigh Holmes (179132), Dai Wang, Andrew J. Roe (107419), Holmes, Ashleigh, Cecilia S. Lindestam Arlehamn (179138), Lindestam Arlehamn, Cecilia S, Dai Wang (73589), Cecilia S Lindestam Arlehamn, Tom J. Evans (179147), Tim J. Mitchell (179143), Andrew J Roe, Evans, Tom J, Mitchell, T.J., Evans Tom J., Schmidt, E.E., Holmes, A., Roe, A.J., Lindestam Arlehamn, C.S., Roe Andrew J., Wang Dai, Lindestam Arlehamn Cecilia S., Mitchell Tim J., Holmes Ashleigh, Wang, D., Evans, T.J.   +30 more
core   +1 more source

Comparative genomics of Xanthomonas fragariae and Xanthomonas arboricola pv. fragariae reveals intra- and interspecies variations

Phytopathology Research, 2020
The quarantine bacterium Xanthomonas fragariae causes angular leaf spots on strawberry. Its population structure was recently found to be divided into four (sub)groups resulting from two distinct main groups. Xanthomonas arboricola pv.
Michael Gétaz, Jochen Blom, Theo H. M. Smits, Joël F. Pothier   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. [PDF]

, 2009
Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for severe gastric diseases, including gastric cancer.
Haas, Rainer, Rainer Haas, Kapp, Ulrike, Jung, Kirsten, Kirsten Jung, Rohde, Manfred, Claudia Ertl, Retta, S. Francesco, S. Francesco Retta, Terradot Laurent, Ertl, Claudia, Luisa F. Jiménez-soto, Luisa F Jiménez-Soto, Fischer Rainer Haas, Retta S. Francesco, Pirch Torsten, Weiss, Evelyn, Xaver Sewald, Jiménez-Soto Luisa F., Wolfgang Fischer, Ertl Claudia, Evelyn Weiss, Jiménez-Soto, Luisa F., Fischer, Wolfgang, Weiss Evelyn, Manfred Rohde, Kutter, Stefan, Kutter Stefan, Pirch, Torsten, Terradot, Laurent, Sewald, Xaver, Fischer Wolfgang, Torsten Pirch, Laurent Terradot, S Francesco Retta, Haas Rainer, Rohde Manfred, Kapp Ulrike, Ulrike Kapp, Retta, Saverio Francesco, Stefan Kutter, Jung Kirsten, Sewald Xaver   +42 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Deciphering interplay between Salmonella invasion effectors. [PDF]

, 2008
Bacterial pathogens have evolved a specialized type III secretion system (T3SS) to translocate virulence effector proteins directly into eukaryotic target cells.
Robert J Cain, Koronakis, Vassilis, Cain Robert J., Hayward, RD, Koronakis, V, Hayward, Richard D, Richard D Hayward, Isberg, R.R., Hayward, Richard D., Koronakis, V., Vassilis Koronakis, Cain, Robert J, Cain, RJ, Hayward Richard D., Cain, R.J., Koronakis Vassilis   +15 more
core   +2 more sources

Control of type III protein secretion using a minimal genetic system

Nature Communications, 2017
The type III secretion system is a needle-like molecular machine under tight regulatory control. Here the authors construct a synthetic type III secretion system gene cluster by deconstructing and rebuilding the wild-typeSalmonellapathogenicity island 1.
Miryoung Song, David J. Sukovich, Luciano Ciccarelli, Julia Mayr, Jesus Fernandez-Rodriguez, Ethan A. Mirsky, Alex C. Tucker, D. Benjamin Gordon, Thomas C. Marlovits, Christopher A. Voigt   +9 more
doaj   +1 more source

T3DB: an integrated database for bacterial type III secretion system

BMC Bioinformatics, 2012
Background Type III Secretion System (T3SS), which plays important roles in pathogenesis or symbiosis, is widely expressed in a variety of gram negative bacteria. However, lack of unique nomenclature for T3SS genes has hindered T3SS related research.
Wang Yejun, Huang He, Sun Ming’an, Zhang Qing, Guo Dianjing   +4 more
doaj   +1 more source