Results 81 to 90 of about 26,046,637 (294)

Microreview: type IV secretion systems: versatility and diversity in function [PDF]

, 2010
Type IV secretion systems (T4SSs) are large protein complexes which traverse the cell envelope of many bacteria. They contain a channel through which proteins or protein–DNA complexes can be translocated.
Angel Rivera-Calzada, Walldén, Karin, Waksman, Gabriel, Rivera-Calzada, A., Karin Wallden, Gabriel Waksman   +5 more
core   +1 more source

Assessing toxicity and competitive fitness of Vibrio isolates from coastal waters in Israel

mSphere
Several species of aquatic bacteria belonging to the genus Vibrio are emerging pathogens of humans and marine animals. Vibrio-associated infections have been shown to correlate with the increase in the oceans’ surface water temperatures.
Katarzyna Kanarek, Kinga Keppel, Hadar Cohen, Chaya Mushka Fridman, Motti Gerlic, Dor Salomon   +5 more
doaj   +1 more source

The type III secretion system needle, tip, and translocon [PDF]

Protein Science, 2019
AbstractMany Gram‐negative bacteria pathogenic to plants and animals deploy the type III secretion system (T3SS) to inject virulence factors into their hosts. All bacteria that rely on the T3SS to cause infectious diseases in humans have developed antibiotic resistance.
Supratim Dey, Amritangshu Chakravarty, Pallavi Guha Biswas, Roberto N. De Guzman   +3 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Structural and Functional Insights into the Pilotin-Secretin Complex of the Type II Secretion System [PDF]

, 2012
PMCID: PMC3276575This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Rehman Saima, Shuang Gu (184317), Rehman, S., Richard W Pickersgill, Pickersgill, R. W., Gu, S, Gu, S., Shuang Gu, Shevchik Vladimir E., Shevchik, V. E., Shevchik, VE, Pickersgill, RW, Wang, X., Wang, X, Vladimir E Shevchik, Xiaohui Wang (19899), Xiaohui Wang, Rehman, S, Vladimir E. Shevchik (184325), Gu Shuang, Pickersgill Richard W., Saima Rehman (184320), Richard W. Pickersgill (87514), Shevchik, Vladimir, Saima Rehman, Wang Xiaohui   +25 more
core   +1 more source

Higher Prevalence of PldA, a Pseudomonas aeruginosa Trans-Kingdom H2-Type VI Secretion System Effector, in Clinical Isolates Responsible for Acute Infections and in Multidrug Resistant Strains

Frontiers in Microbiology, 2018
Pseudomonas aeruginosa can manipulate eukaryotic host cells using secreted effectors delivered by the type III or the type VI Secretion Systems (T3SS and T6SS). The T3SS allows the injection of bacterial effectors (Exo toxins) into eukaryotic cell.
Thibaud Boulant, Yves-Marie Boudehen, Alain Filloux, Patrick Plesiat, Thierry Naas, Thierry Naas, Thierry Naas, Laurent Dortet, Laurent Dortet, Laurent Dortet, Laurent Dortet   +10 more
doaj   +1 more source

FlgM as a Secretion Moiety for the Development of an Inducible Type III Secretion System

PLoS ONE, 2013
Regulation and assembly of the flagellar type III secretion system is one of the most investigated and best understood regulational cascades in molecular biology. Depending on the host organism, flagellar morphogenesis requires the interplay of more than 50 genes.
Thomas Heel, Georg F Vogel, Andrea Lammirato, Rainer Schneider, Bernhard Auer   +4 more
openaire   +4 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Genome-wide Investigation of Vibrio parahaemolyticus Type III Secretion System-1 Regulation and Chitin Metabolism

, 2022
Vibrio parahaemolyticus is the leading cause of seafood-borne gastroenteritis in humans following the consumption of contaminated seafood, and is a consequential organism for aquaculture and human health.
Getz, Landon John
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source