Results 81 to 90 of about 27,335,054 (258)

Regulation of the Type III Secretion System in Phytopathogenic Bacteria

Molecular Plant-Microbe Interactions, 2006
The type III secretion system (TTSS) is a specialized protein secretion machinery used by numerous gram-negative bacterial pathogens of animals and plants to deliver effector proteins directly into the host cells.
Xiaoyan Tang, Yanmei Xiao, Jian-Min Zhou
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Antibodies Inhibiting the Type III Secretion System of Gram-Negative Pathogenic Bacteria

Antibodies, 2020
Pathogenic bacteria are a global health threat, with over 2 million infections caused by Gram-negative bacteria every year in the United States. This problem is exacerbated by the increase in resistance to common antibiotics that are routinely used to ...
Julia A. Hotinger, Aaron E. May
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

From gut colonization to recurrence: E. coli secretion systems at the host-microbiota interface

Gut Microbes
Escherichia coli occupies a unique position between commensal colonization and infection. It is a common member of the intestinal microbiota, yet selected pathogenic or opportunistic lineages can persist in mucosal niches, interact with resident ...
Marcin Równicki, Maciej Obrębski, Jakub P. Piwowarski   +2 more
doaj   +1 more source

Control of type III protein secretion using a minimal genetic system

Nature Communications, 2017
The type III secretion system is a needle-like molecular machine under tight regulatory control. Here the authors construct a synthetic type III secretion system gene cluster by deconstructing and rebuilding the wild-typeSalmonellapathogenicity island 1.
Miryoung Song, David J. Sukovich, Luciano Ciccarelli, Julia Mayr, Jesus Fernandez-Rodriguez, Ethan A. Mirsky, Alex C. Tucker, D. Benjamin Gordon, Thomas C. Marlovits, Christopher A. Voigt   +9 more
doaj   +1 more source

T3DB: an integrated database for bacterial type III secretion system

BMC Bioinformatics, 2012
Background Type III Secretion System (T3SS), which plays important roles in pathogenesis or symbiosis, is widely expressed in a variety of gram negative bacteria. However, lack of unique nomenclature for T3SS genes has hindered T3SS related research.
Wang Yejun, Huang He, Sun Ming’an, Zhang Qing, Guo Dianjing   +4 more
doaj   +1 more source

Deciphering interplay between Salmonella invasion effectors. [PDF]

, 2008
Bacterial pathogens have evolved a specialized type III secretion system (T3SS) to translocate virulence effector proteins directly into eukaryotic target cells.
Robert J Cain, Koronakis, Vassilis, Cain Robert J., Hayward, RD, Koronakis, V, Hayward, Richard D, Richard D Hayward, Isberg, R.R., Hayward, Richard D., Koronakis, V., Vassilis Koronakis, Cain, Robert J, Cain, RJ, Hayward Richard D., Cain, R.J., Koronakis Vassilis   +15 more
core   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

TtsI: Beyond Type III Secretion System Activation in Rhizobia

Applied Microbiology
The expression of the rhizobial symbiotic genes is controlled by various transcriptional regulators. After induction with appropriate plant flavonoids, NodD is responsible for the activation of the expression of genes related to Nod factor synthesis and ...
Irene Jiménez-Guerrero, Sebastián Acosta-Jurado, Pilar Navarro-Gómez, Francisco Fuentes-Romero, Cynthia Alías-Villegas, Francisco-Javier López-Baena, José-María Vinardell   +6 more
doaj   +1 more source