Results 61 to 70 of about 26,046,637 (294)

The Architecture of the Cytoplasmic Region of Type III Secretion Systems [PDF]

Scientific Reports, 2016
AbstractType III secretion systems (T3SSs) are essential devices in the virulence of many Gram-negative bacterial pathogens. They mediate injection of protein effectors of virulence from bacteria into eukaryotic host cells to manipulate them during infection. T3SSs involved in virulence (vT3SSs) are evolutionarily related to bacterial flagellar protein
Makino, Fumiaki, Shen, Dakang, Kajimura, Naoko, Kawamoto, Akihiro, Pissaridou, Panayiota, Oswin, Henry, Pain, Maria, Murillo Cabeza, Isabel, Namba, Keiichi, Blocker, Ariel J   +9 more
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

YscP, a key player in the type three secretion system of "Yersinia enterocolitica" [PDF]

, 2005
The Yersinia injectisome needle has a constant length of around 60nm. Mutants affected in the yscP gene display abnormally long needles, suggesting that needle length is genetically controlled and that YscP is involved in this process. First, both N- and
Agrain, Céline
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Characterisation of the effects of salicylidene acylhydrazide compounds on type three secretion in Escherichia coli O157:H7 [PDF]

, 2009
Recent work has highlighted a number of compounds that target bacterial virulence by affecting gene regulation. In this work, we show that small-molecule inhibitors affect the expression of the type III secretion system (T3SS) of <i>Escherichia ...
Layton, Abigail, Stevens, M. P., Tree, J.J., Stevens, Mark P, Tree, J. J., Roe, A. J., McInally, C., Roe, Andrew J, Tree, Jai J, Wang, Dai, Elofsson, M., Houghton, I., Mahajan, A., Stevens, M.P., Gally, D. L., Roe, A.J., Wang, D., Gally, D.L., Layton, A., Elofsson, Mikael,, McInally, Carol, Houghton, Irene, Mahajan, Arvind, Gally, David L   +23 more
core   +1 more source

Lactoferrin inhibits E. coli O157:H7 growth and attachment to intestinal epithelial cells

Veterinární Medicína, 2010
Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 strains are associated with haemorraghic colitis and haemolytic uremic syndrome (HUS) in humans. Cattle are a reservoir of E. coli O157:H7. We studied the ability of bovine and human lactoferrin,
M. Atef Yekta, F. Verdonck, W. Van Den Broeck, B.M. Goddeeris, E. Cox, D. Vanrompay   +5 more
doaj   +1 more source

Expression of and secretion through the Aeromonas salmonicida type III secretion system [PDF]

Microbiology, 2006
Aeromonas salmonicida subsp. salmonicida is the aetiological agent of furunculosis, a disease of farmed and wild salmonids. The type III secretion system (TTSS) is one of the primary virulence factors in A. salmonicida. Using a combination of differential proteomic analysis and reverse transcriptase (RT)-PCR, it is shown that A ...
Ebanks, Roger O., Knickle, Leah C., Goguen, Michel, Boyd, Jessica M., Pinto, Devanand M., Reith, Michael, Ross, Neil W.   +6 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Established microbial colonies can survive type VI secretion assault [PDF]

, 2015
Type VI secretion (T6S) is a cell-to-cell injection system that can be used as a microbial weapon. T6S kills vulnerable cells, and is present in close to 25% of sequenced Gram-negative bacteria.
Ned S Wingreen, Marek Basler (173162), Basler, Marek, Ringel, Peter, David Bruce Borenstein, Peter Ringel (816293), Borenstein, David Bruce, Peter Ringel, Wingreen, Ned S., Wingreen, Ned, Marek Basler, David Bruce Borenstein (413437), Ned S. Wingreen (10926)   +12 more
core   +2 more sources

Antibacterial Effect of Berberrubine on the Type III Secretion System

Natural Product Communications, 2023
The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against ...
Won-Sik Choi, Tae-Hun Lee, Se-Jin Son, Yeo Reum Park, Tae-Young Lee, Ahsan Javed, Deokyeong Choe, Solomon L Kim, Sung Uk Kim, Sang-Han Lee   +9 more
doaj   +1 more source