Results 61 to 70 of about 27,335,054 (258)

Functional regulation and cross-talk of type III and type VI secretion systems in Salmonella

Virulence
In Salmonella, the type III and type VI secretion systems (T3SS and T6SS) play critical roles in pathogenicity. The bacterium harbors two distinct T3SSs: T3SS-1, encoded by SPI-1, promotes host cell invasion, whereas T3SS-2 (located within SPI-2 ...
Xingyi Li, Ying Ding, Yu Sun, Yiting Gu, Wanli Feng, Yanyan Jia, Huimin Chen, Songbiao Chen   +7 more
doaj   +1 more source

Higher Prevalence of PldA, a Pseudomonas aeruginosa Trans-Kingdom H2-Type VI Secretion System Effector, in Clinical Isolates Responsible for Acute Infections and in Multidrug Resistant Strains

Frontiers in Microbiology, 2018
Pseudomonas aeruginosa can manipulate eukaryotic host cells using secreted effectors delivered by the type III or the type VI Secretion Systems (T3SS and T6SS). The T3SS allows the injection of bacterial effectors (Exo toxins) into eukaryotic cell.
Thibaud Boulant, Yves-Marie Boudehen, Alain Filloux, Patrick Plesiat, Thierry Naas, Thierry Naas, Thierry Naas, Laurent Dortet, Laurent Dortet, Laurent Dortet, Laurent Dortet   +10 more
doaj   +1 more source

Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components

Biomolecules, 2021
The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for millions of infections yearly. Since many T3SS knockout strains are incapable
Julia A. Hotinger, Heather A. Pendergrass, Aaron E. May   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Characterization of Pseudomonas alliivorans strains isolated from Georgia, USA: insights into genomic diversity and pathogenicity in onions

Applied and Environmental Microbiology
Pseudomonas alliivorans is an important emerging pathogen affecting numerous crops. The species is closely related to Pseudomonas viridiflava, with which P. alliivorans strains were often misidentified in the past.
Mei Zhao, Michelle Pena Maclellan, Anuj Lamichhane, Sujan Paudel, Ron Gitaitis, Brian Kvitko, Bhabesh Dutta   +6 more
doaj   +1 more source

Animal Models of Type III Secretion System-Mediated Pathogenesis

Pathogens, 2019
The type III secretion system (T3SS) is a conserved virulence factor used by many Gram-negative pathogenic bacteria and has become an important target for anti-virulence drugs.
Julia A. Hotinger, Aaron E. May
doaj   +1 more source

Assembly and arrangement of the type three secretion system of "yersinia enterocolitica" [PDF]

, 2014
The type three secretion system (T3SS) is a bacterial weapon found in many Gram-negative bacteria. It consists out of a needle like structure called injectisome, which enables bacteria to inject effector proteins into eukaryotic cells. The injectisome is
Amstutz, Marlise
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Migration of Type III Secretion System Transcriptional Regulators Links Gene Expression to Secretion

mBio, 2018
Many plant-pathogenic bacteria of considerable economic importance rely on type III secretion systems (T3SSs) of the Hrc-Hrp 1 family to subvert their plant hosts.
Spyridoula N. Charova, Anastasia D. Gazi, Efstratios Mylonas, Charalambos Pozidis, Blanca Sabarit, Dimitrios Anagnostou, Konstantina Psatha, Michalis Aivaliotis, Carmen R. Beuzon, Nickolas J. Panopoulos, Michael Kokkinidis   +10 more
doaj   +1 more source