Results 91 to 100 of about 26,046,637 (294)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Detection of type III secretion genes as a general indicator of bacterial virulence [PDF]

, 2003
Type III secretion systems of Gram-negative bacteria are specific export machineries for virulence factors which allow their translocation to eukaryotic cells.
Frey, Joachim, Stuber, Katja, Burnens, André P., Kuhnert, Peter   +3 more
core   +1 more source

Characterization of Pseudomonas alliivorans strains isolated from Georgia, USA: insights into genomic diversity and pathogenicity in onions

Applied and Environmental Microbiology
Pseudomonas alliivorans is an important emerging pathogen affecting numerous crops. The species is closely related to Pseudomonas viridiflava, with which P. alliivorans strains were often misidentified in the past.
Mei Zhao, Michelle Pena Maclellan, Anuj Lamichhane, Sujan Paudel, Ron Gitaitis, Brian Kvitko, Bhabesh Dutta   +6 more
doaj   +1 more source

Migration of Type III Secretion System Transcriptional Regulators Links Gene Expression to Secretion

mBio, 2018
Many plant-pathogenic bacteria of considerable economic importance rely on type III secretion systems (T3SSs) of the Hrc-Hrp 1 family to subvert their plant hosts.
Spyridoula N. Charova, Anastasia D. Gazi, Efstratios Mylonas, Charalambos Pozidis, Blanca Sabarit, Dimitrios Anagnostou, Konstantina Psatha, Michalis Aivaliotis, Carmen R. Beuzon, Nickolas J. Panopoulos, Michael Kokkinidis   +10 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The tip complex of the "Yersinia enterocolitica" injectisome [PDF]

, 2008
Type III secretion systems are used by many pathogenic bacteria to deliver effector proteins into host cells. The secretion machinery, also known as the injectisome, is composed of a basal body anchored in the bacterial membranes and an external needle ...
Müller, Catherine Ann
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Structure of a bacterial type IV secretion core complex at subnanometre resolution [PDF]

, 2013
Type IV secretion (T4S) systems are able to transport DNAs and/or proteins through the membranes of bacteria. They form large multiprotein complexes consisting of 12 proteins termed VirB1-11 and VirD4.
Steyaert, J., Pardon, E, Savva, CG, Lian, Pei W., Fronzes, Remi, Waksman, Gabriel, Orlova, Elena, Orlova, EV, Remaut, Han, Chandran, Vidya, Fronzes, R, Laeremans, T., Chandran, V, Lian, PW, Steyaert, J, Laeremans, T, Rivera-Calzada, A., Remaut, H, Pardon, E., Waksman, G, Rivera-Calzada, A, Savva, Christos G.   +21 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]

, 2013
Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Redzej, Adam, Topf, Maya, Zechner, E.L., Lang, S., Waksman, Gabriel, Zangger, K., Gruber, C.J., Ilangovan, Aravindan   +7 more
core   +1 more source