Results 1 to 10 of about 25,865 (227)

Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components. [PDF]

Biomolecules, 2021
The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for millions of infections yearly. Since many T3SS knockout strains are incapable
Hotinger JA, Pendergrass HA, May AE.
europepmc   +6 more sources

Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species. [PDF]

Microorganisms, 2023
The nanomachine referred to as the type III secretion system (T3SS) is used by many Gram-negative pathogens or symbionts to inject their effector proteins into host cells to promote their infections or symbioses.
Zakaria D, Matsuda S, Iida T, Hayashi T, Arita M.   +4 more
europepmc   +5 more sources

The Type III Secretion System (T3SS) is a Determinant for Rice-Endophyte Colonization by Non-Photosynthetic Bradyrhizobium. [PDF]

Microbes Environ, 2015
Plant associations by bradyrhizobia have been detected not only in leguminous plants, but also in non-leguminous species including rice. Bradyrhizobium sp.
Piromyou P, Songwattana P, Greetatorn T, Okubo T, Kakizaki KC, Prakamhang J, Tittabutr P, Boonkerd N, Teaumroong N, Minamisawa K.   +9 more
europepmc   +5 more sources

The Type III Secretion System (T3SS)-Translocon of Atypical Enteropathogenic Escherichia coli (aEPEC) Can Mediate Adherence. [PDF]

Front Microbiol, 2019
The intimin protein is the major adhesin involved in the intimate adherence of atypical enteropathogenic Escherichia coli (aEPEC) strains to epithelial cells, but little is known about the structures involved in their early colonization process.
Santos FF, Yamamoto D, Abe CM, Bryant JA, Hernandes RT, Kitamura FC, Castro FS, Valiatti TB, Piazza RMF, Elias WP, Henderson IR, Gomes TAT.   +11 more
europepmc   +7 more sources

Beyond pathogenicity: applications of the type III secretion system (T3SS) of <i>Pseudomonas aeruginosa</i>. [PDF]

Front Microbiol
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa employs its type III secretion system (T3SS) as a pivotal factor in facilitating the injection of effector proteins into host cells.
Su T, Zhang L, Shen J, Qian D, Guo Y, Li Z.   +5 more
europepmc   +4 more sources

Computational approach to predict species-specific type III secretion system (T3SS) effectors using single and multiple genomes. [PDF]

BMC Genomics, 2016
Many gram-negative bacteria use type III secretion systems (T3SSs) to translocate effector proteins into host cells. T3SS effectors can give some bacteria a competitive edge over others within the same environment and can help bacteria to invade the host
Hobbs CK, Porter VL, Stow ML, Siame BA, Tsang HH, Leung KY.   +5 more
europepmc   +5 more sources

Protein Export via the Type III Secretion System of the Bacterial Flagellum

Biomolecules, 2021
The bacterial flagellum and the related virulence-associated injectisome system of pathogenic bacteria utilize a type III secretion system (T3SS) to export substrate proteins across the inner membrane in a proton motive force-dependent manner.
Manuel Halte, Marc Erhardt
doaj   +2 more sources

Harmine, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium

Frontiers in Cellular and Infection Microbiology, 2022
New therapeutic strategies for clinical Salmonella enterica serovar Typhimurium (S. Typhimurium) infection are urgently needed due to the generation of antibiotic-resistant bacteria.
Yunjia Shi, Xindi Chen, Jingyan Shu, Yang Liu, Yong Zhang, Qianghua Lv, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu   +9 more
doaj   +2 more sources

Regulation of the Pseudomonas syringae Type III Secretion System by Host Environment Signals

Microorganisms, 2021
Pseudomonas syringae are Gram-negative, plant pathogenic bacteria that use a type III secretion system (T3SS) to disarm host immune responses and promote bacterial growth within plant tissues. Despite the critical role for type III secretion in promoting
Megan R. O’Malley, Jeffrey C. Anderson
doaj   +2 more sources

Berberine Hydrochloride Reduces the Intracellular Survival of Salmonella Typhimurium by Enhancing Host Autophagic Flux Through the Inhibition of the Type III Secretion System [PDF]

Biomolecules
Salmonella Typhimurium, a significant intracellular foodborne pathogen, regulates host cell autophagy to achieve its own survival by injecting effector proteins into host cells via its type III secretion system (T3SS).
Jianan Huang, Jiaxing Lu, Conghui Wu, Sidi Chen, Tianyuan Chang, Lei Xu, Xihui Shen, Qadir Bakhsh, Baofu Qin, Weidong Qian, Yao Wang   +10 more
doaj   +2 more sources