Structural basis of eukaryotic cell targeting by type III secretion system (T3SS) effectors.
Research in Microbiology, 2013 Type III secretion systems (T3SS) are macromolecular complexes that translocate a wide number of effector proteins into eukaryotic host cells. Once within the cytoplasm, many T3SS effectors mimic the structure and/or function of eukaryotic proteins in order to manipulate signaling cascades, and thus play pivotal roles in colonization, invasion ...
T. Tosi +4 more
semanticscholar +4 more sources
Emerging insights into the type I secretion system: a key player in Salmonella virulence and host-pathogen interactions [PDF]
mBioSalmonella spp. are major zoonotic bacterial pathogens that can cause a range of diseases in both humans and animals, including gastroenteritis, septicemia, and typhoid fever. During intestinal colonization, Salmonella relies on the coordinated action of
Siqi Li, Hongtao Liu, Jiazhang Qiu
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Systemic Translocation of Salmonella enterica Serovar Dublin in Cattle Occurs Predominantly via Efferent Lymphatics in a Cell-Free Niche and Requires Type III Secretion System 1 (T3SS-1) but Not T3SS-2 [PDF]
Infection and Immunity, 2007 ABSTRACT Salmonella enterica is an important diarrheal pathogen, and infections may involve severe systemic sequelae depending on serovar- and host-specific factors. The molecular mechanisms underlying translocation of host-restricted and -specific serovars of S. enterica
G. Pullinger +9 more
semanticscholar +4 more sources
Pilotins are mobile T3SS components involved in assembly and substrate specificity of the bacterial type III secretion system [PDF]
Molecular Microbiology, 2022 AbstractIn animal pathogens, assembly of the type III secretion system injectisome requires the presence of so-called pilotins, small lipoproteins that assist the formation of the secretin ring in the outer membrane. Using a combination of functional assays, interaction studies, proteomics, and live-cell microscopy, we determined the contribution of ...
Stephan Wimmi +8 more
openaire +4 more sources
Bcr4 Is a Chaperone for the Inner Rod Protein in the Bordetella Type III Secretion System
Microbiology Spectrum, 2022 Bordetella bronchiseptica injects virulence proteins called effectors into host cells via a type III secretion system (T3SS) conserved among many Gram-negative bacteria.
Masataka Goto +4 more
doaj +1 more source
Diversity of virulence phenotypes among type III secretion negative Pseudomonas aeruginosa clinical isolates. [PDF]
PLoS ONE, 2014 Pseudomonas aeruginosa is a frequent cause of acute infections. The primary virulence factor that has been linked to clinical disease is the type III secretion system, a molecular syringe that delivers effector proteins directly into host cells.
Jonida Toska +6 more
doaj +1 more source
Engineering Agrobacterium tumefaciens with a Type III Secretion System to Express Type III Effectors
Bio-Protocol, 2023 Plants elicit defense responses when exposed to pathogens, which partly contribute to the resistance of plants to Agrobacterium tumefaciens–mediated transformation.
Vidhyavathi Raman, Kirankumar Mysore
doaj +1 more source
Nature Communications, 2021 Many bacterial pathogens use a type III secretion system (T3SS) to inject effector proteins into host cells. Here, Wimmi et al. show that the external pH regulates the assembly of T3SS cytosolic components in intestinal pathogens, thus preventing T3SS ...
Stephan Wimmi +10 more
doaj +1 more source
The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]
, 2016 Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie +2 more
core +5 more sources
Nature Communications, 2022 Agrobacterium-mediated plant transformation (AMT) is the basis of modern-day plant biotechnology. One major drawback of this technology is the recalcitrance of many plant species/varieties to Agrobacterium infection, most likely caused by elicitation of ...
V. Raman +11 more
semanticscholar +1 more source