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Type VII Collagen Disorders Simplified
CutisEpidermolysis bullosa acquisita (EBA) and bullous systemic lupus erythematosus (BSLE) are autoimmune mechanobullous diseases that are caused by autoantibodies directed against type VII collagen. The functionality of type VII collagen is vital to the skin and mucous membranes because it makes up the anchoring fibrils that adhere the epithelium to the ...
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Autoimmunity to type VII collagen.
Seminars in dermatology, 1991The epidermolysis bullosa acquisita (EBA) antigen is type VII collagen that is found within the anchoring fibrils of the basement membrane zone beneath stratified epithelia. Autoimmunity to the EBA antigen/type VII collagen has been associated with three diseases: EBA, bullous systemic lupus erythematosus (SLE) and a subset of linear IgA bullous ...
D T, Woodley, Y, Sarret, R A, Briggaman
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Nature Medicine, 2004
Dystrophic epidermolysis bullosa (DEB) is a family of inherited mechano-bullous disorders that are caused by mutations in the type VII collagen gene and for which ex vivo gene therapy has been considered. To develop a simpler approach for treating DEB, we evaluated the feasibility of protein-based therapy by intradermally injecting human recombinant ...
David T, Woodley +6 more
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Dystrophic epidermolysis bullosa (DEB) is a family of inherited mechano-bullous disorders that are caused by mutations in the type VII collagen gene and for which ex vivo gene therapy has been considered. To develop a simpler approach for treating DEB, we evaluated the feasibility of protein-based therapy by intradermally injecting human recombinant ...
David T, Woodley +6 more
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Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen
Journal of the American Academy of Dermatology, 2002We describe a 73-year-old patient who had a subepidermal bullous eruption develop after a course of antibiotics, including vancomycin. The patient had deposits of IgA and IgG in the cutaneous basement membrane zone that were located on the dermal side of 1 M NaCl-treated autologous skin. By an enzyme-linked immunosorbent assay, the patient was found to
Delbaldo, Catherine Suzanne +7 more
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Epidermolysis bullosa acquisita: A disease of autoimmunity to type VII collagen
Journal of Autoimmunity, 1991Epidermolysis bullosa acquisita (EBA) is one of a group of primary blistering diseases characterized by dermal/epidermal separation at the basement membrane (BM) of stratified squamous epithelium and IgG anti-BM autoantibodies (ABM). EBA ABMs can be distinguished from IgG ABMs in all other primary blistering diseases by their reactivity with the BM ...
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Type VII Collagen and 19-DEJ-1 Antigen
Archives of Dermatology, 1990• The expression of type VII collagen and 19-DEJ-1 antigen was examined in 73 and 71 patients, respectively, with recessive dystrophic epidermolysis bullosa (RDEB), comprising gravis, mitis, inversa, and indeterminant subsets, to better determine the specificity and sensitivity of two monoclonal antibodies directed against these dermoepidermal ...
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The Structure and Function of Type VII Collagen
Annals of the New York Academy of Sciences, 1990R E, Burgeson +5 more
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Anchoring fibrils and type VII collagen in human breast.
Journal of submicroscopic cytology and pathology, 1990A correlated ultrastructural and immunofluorescent study of anchoring fibrils and their principal constituent, type VII collagen, has been carried out on lobular epithelium from the normal adult human breast at different times in the menstrual cycle. Throughout the cycle, characteristic, cross-banded anchoring fibrils were seen inserting into the area ...
B P, Eyden, J, Ferguson
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Intraepidermal type VII collagen
Journal of the American Academy of Dermatology, 1990Jo-David Fine +4 more
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