Results 191 to 200 of about 22,420 (243)
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Prenylated flavonoids as tyrosinase inhibitors
Archives of Pharmacal Research, 2004In order to find new tyrosinase inhibitors and the effects of prenyl residue on flavonoid molecules, eight prenylated and three synthetic vinylated flavonoids were examined on their inhibitory effect against tyrosinase activity. From the results, kuwanon C, papyriflavonol A, sanggenon D and sophoflavescenol were found to possess the considerable ...
Nan Kyoung, Lee +6 more
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Tyrosinase and Tyrosinase Inhibitors
Journal of Biocatalysis & Biotransformation, 2012Tyrosinase and Tyrosinase Inhibitors Melanin is responsible for skin color and plays an important role in protection of the skin against UV light induced damage. During the melanin biosynthesis pathway, tyrosinase (EC 1.14.18.1) is the rate-limiting enzyme that hydroxylates L-tyrosine to L-3,4- dihydroxyphenylalanine (L-DOPA), and L-DOPA is further ...
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British Journal of Dermatology, 1981
Purification of tyrosinase inhibitors of hamster melanomas was carried out using tyrosinase binding affinity column chromatography. This method enables the isolation of tyrosinase inhibitors with a 124-fold purification index as compared to that of crude preparation after dialysation.
G, Imokawa, Y, Mishima
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Purification of tyrosinase inhibitors of hamster melanomas was carried out using tyrosinase binding affinity column chromatography. This method enables the isolation of tyrosinase inhibitors with a 124-fold purification index as compared to that of crude preparation after dialysation.
G, Imokawa, Y, Mishima
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Tyrosinase Inhibitors from Bolivian Medicinal Plants
Journal of Natural Products, 1995Bioassay-guided fractionation monitored by mushroom tyrosinase (EC 1.14.18.1) activity, afforded six inhibitors from three Bolivian medicinal plants, Buddleia coriacea, Gnaphalium cheiranthifolium, and Scheelea princeps. These inhibitors, which are all known phenolic compounds, inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) mediated ...
I, Kubo, Y, Yokokawa, I, Kinst-Hori
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Tyrosinase inhibitors as potential antibacterial agents
European Journal of Medicinal Chemistry, 2020Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses and the undesirable browning of fruits and vegetables.
Ye Yuan +7 more
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Tyrosinase Inhibitors from Cumin
Journal of Agricultural and Food Chemistry, 1998Cuminaldehyde (p-isopropylbenzaldehyde) was identified as a potent mushroom tyrosinase inhibitor from cumin, a common food spice. This benzaldehyde derivative was found to inhibit the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) by mushroom tyrosinase with an ID50 of 7.7 μg/mL (0.05 mM). Its oxidized analogue, cumic acid (p-isopropylbenzoic acid),
Isao Kubo, Ikuyo Kinst-Hori
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Tyrosinase Inhibitor from Black Rice Bran
Journal of Agricultural and Food Chemistry, 2003The inhibitor of tyrosinase activity in black rice bran was investigated. The methanol extract from black rice bran was re-extracted with hexane, chloroform, ethyl acetate, or water. The ethyl acetate extract had the most potent inhibition against tyrosinase activity by 80.5% at a concentration of 0.4 mg/mL.
Mitsuo, Miyazawa +4 more
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Tyrosinase Inhibitors from Anacardium occidentale Fruits
Journal of Natural Products, 1994Anacardic acids, 2-methylcardols, and cardols isolated from various parts of the cashew [Anacardium occidentale] (Anacardiaceae) fruit have been found to exhibit tyrosinase inhibitory activity. Kinetic studies with the two principal active compounds, 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid and 5-[8(Z),11(Z),14-pentadecatrienyl]resorcinol, have
I, Kubo, I, Kinst-Hori, Y, Yokokawa
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Journal of Experimental Biology, 1955
ABSTRACT It has been reported that if Drosophila larvae are ground to a fine paste with sand, the homogenate shows little tyrosinase activity, but that if the larvae are allowed to blacken in chloroform vapour before grinding, activity is increased.
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ABSTRACT It has been reported that if Drosophila larvae are ground to a fine paste with sand, the homogenate shows little tyrosinase activity, but that if the larvae are allowed to blacken in chloroform vapour before grinding, activity is increased.
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New saccharin derivatives as tyrosinase inhibitors
Bioorganic & Medicinal Chemistry, 2012A newly series of 6-(phenylurenyl/thiourenyl) saccharin (6a-y) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. A 70-fold purification of the enzyme with 6.85% yield was achieved by using a Sepharose 4B-l-tyrosine-p-amino benzoic acid affinity column.
Gençer, Nahit +3 more
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