Results 201 to 210 of about 22,420 (243)
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Thiosemicarbazones as inhibitors of tyrosinase enzyme
Bioorganic & Medicinal Chemistry Letters, 2017In the search for compounds which may inhibit the development of melanomas, a series of thiosemicarbazones has been investigated as possible inhibitors of the tyrosinase enzyme. The results showed that all the thiosemicarbazones tested exhibited significant inhibitory effects on the enzyme.
Mariana A, Soares +5 more
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Tyrosinase Inhibitors from Artocarpus gomezianus
Planta Medica, 2000Eight compounds including, phenyl-beta-naphthylamine (1), isocyclomorusin (2), cycloartocarpin (3), artocarpin (4), norartocarpetin (5), cudraflavone C (6), albanin A (7), and resveratrol (8) were isolated from the roots of Artocarpus gomezianus. Compounds 5 and 8 exhibited potent tyrosinase inhibitory activity.
K, Likhitwitayawuid +2 more
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Recent advances in triazoles as tyrosinase inhibitors
European Journal of Medicinal Chemistry, 2023The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a significant position in melanogenesis, plays an important role in undesirable browning of fruits and vegetables, antibiotic resistance, skin pigment formation, sclerotization of cuticle, neurodegeneration, etc. Therefore, with the wide potential application fields
Arif Mermer, Serpil Demirci
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Biomedical applications of tyrosinases and tyrosinase inhibitors
Tyrosinase is involved in several human diseases, among which hypopigmentation and depigmentation conditions (vitiligo, idiopathic guttate hypomelanosis, pityriasis versicolor, pityriasis alba) and hyperpigmentations (melasma, lentigines, post-inflammatory and periorbital hyperpigmentation, cervical idiopathic poikiloderma and acanthosis nigricans ...Luigi, Pisano +2 more
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New halogenated phenylcoumarins as tyrosinase inhibitors
Bioorganic & Medicinal Chemistry Letters, 2011With the aim to find out structural features for the tyrosinase inhibitory activity, in the present communication we report the synthesis and pharmacological evaluation of a new series of phenylcoumarin derivatives with different number of hydroxyl or ether groups and bromo substituent in the scaffold.
Matos MJ +7 more
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New Tyrosinase Inhibitors, (+)-Catechin−Aldehyde Polycondensates
Biomacromolecules, 2004In this study, new tyrosinase inhibitors, (+)-catechin-aldehyde polycondensates, have been developed. Tyrosinase is a copper-containing enzyme that catalyzes the hydroxylation of a monophenol (monophenolase activity) and the oxidation of an o-diphenol (diphenolase activity).
Young-Jin, Kim +4 more
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Bacterial tyrosinases and their inhibitors
Bacterial tyrosinase is a copper-containing metalloenzyme with diverse physio-chemical properties, that have been identified in various bacterial strains, including actinobacteria and proteobacteria. Tyrosinases are responsible for the rate-limiting catalytic steps in melanin biosynthesis and enzymatic browning.Ali, Irfan +5 more
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Computational studies of tyrosinase inhibitors
Computational studies have significantly advanced the understanding of tyrosinase (TYR) function, mechanism, and inhibition, accelerating the development of more effective and selective inhibitors. This chapter provides an overview of in silico studies on TYR inhibitors, emphasizing key inhibitory chemotypes and the main residues involved in ligand ...Alessandro, Bonardi, Paola, Gratteri
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Natural products as tyrosinase inhibitors
Tyrosinase is a crucial copper-containing enzyme involved in the production of melanin. Melasma, age spots, and freckles are examples of hyperpigmentation diseases caused by excess production of melanin. Inhibiting tyrosinase activity is a crucial method for treating these disorders along with various applications such as cosmetics, food technology ...Aslınur, Doğan, Suleyman, Akocak
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Potent tyrosinase inhibitors fromTrifolium balansae
Natural Product Research, 2006Trifolium balansae (Leguminosae) yielded a phytylester, phytyl-1-hexanoate, three steroids, stigmast-5-ene-3 beta,26-diol, stigmast-5-ene-3-ol and campesterol, and an alcohol, pentacosanol which were reported for the first time from T.balansae. The structures of the isolates were determined by 1D and 2D NMR techniques and MS spectroscopy. Compounds 1-5
Sabudak, Temine +3 more
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