Results 211 to 220 of about 22,420 (243)
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Drug design of tyrosinase inhibitors
This copper-containing enzyme catalyzes the rate-limiting step for the melanin skin pigment bioproduction. Tyrosinase inhibitors can be exploited as skin whitening agents and food preservatives, opening new scenarios in food, cosmetics, agriculture and medicine.Melfi F. +4 more
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Tyrosinase Inhibitors from Anise Oil
Journal of Agricultural and Food Chemistry, 1998Anisaldehyde characterized in the seeds of Pimpinella anisum L. (Umbelliferae), also known as aniseed, was found to inhibit the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) by mushroom tyrosinase (EC 1.14.18.1) with an ID50 of 43 μg/mL (0.32 mM).
Isao Kubo, Ikuyo Kinst-Hori
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Resorcinol alkyl glucosides as potent tyrosinase inhibitors
Bioorganic & Medicinal Chemistry Letters, 2019Resorcinol alkyl glucosides 7-12 were developed as novel tyrosinase inhibitors based on the structure of rhododendrin. These were synthesized from 2,4-dibenzyloxybenzaldehyde using either the Wittig or the Horner-Wadsworth-Emmons reaction with Koenigs-Knorr glycosylation as key steps. The tyrosinase inhibitory activity of 7-12 increased with the length
Wakana Ishioka +3 more
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Mushroom tyrosinase inhibitors from Aloe barbadensis Miller
Fitoterapia, 2012Two new chromones, 5-((S)-2'-oxo-4'-hydroxypentyl)-2-(β-glucopyranosyl-oxy-methyl)chromone (1) and 5-((S)-2'-oxo-4'-hydroxypentyl)-2-methoxychromone (2), together with four known analogues, 8-C-glucosyl-7-O-methyl-(S)-aloesol (3), isoaloeresin D (4), 8-C-glucosyl-(R)-aloesol (5), and aloesin (6) were isolated from the aqueous extract of Aloe ...
Xiaofang, Wu +5 more
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New Tyrosinase Inhibitors from Paecilomyces gunnii
Journal of Agricultural and Food Chemistry, 2014Through screening 50 strains of entomopathogenic fungi and rescreening of 7 strains of Paecilomyces gunnii, a methanol extract of liquid-cultivated mycelia of P. gunnii was found to have the strongest tyrosinase inhibitory activity. Preparative high-speed counter-current chromatography (HSCCC) guided by high-performance liquid chromatography (HPLC ...
Ruili, Lu +10 more
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Tetraketones: A new class of tyrosinase inhibitors
Bioorganic & Medicinal Chemistry, 2006Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC(50)=2.06 microM), 11 (IC(50)=2.09 microM), 15 (IC(50)=2.61 microM), and 27 (IC(50)=3.19 microM) were found to be the most active compounds of the series, even better than both standards kojic acid (IC ...
Khalid Mohammed, Khan +6 more
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Synthesis of glabridin derivatives as tyrosinase inhibitors
Archives of Pharmacal Research, 2009A novel 3'',4''-dihydroglabridin was successfully prepared for studying on tyrosinase inhibitory activity. The result demonstrated that 3'',4''-dihydroglabridin exhibited higher activity than glabridin (IC(50) value = 11.40 microM), which is probably due to the 4-substituted resorcinol skeleton and the lacking of double bond between carbon atom 3'' and
Warunee, Jirawattanapong +2 more
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Tyrosinase Inhibitors from Terrestrial and Marine Resources
Current Topics in Medicinal Chemistry, 2014Tyrosinase is a multifunctional copper-containing enzyme widely distributed in plants and animals, which catalyzes both the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-quinones. Tyrosinase is known to be a key enzyme for melanin biosynthesis in plants and animals.
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Trends in kinase drug discovery: targets, indications and inhibitor design
Nature Reviews Drug Discovery, 2021Misty M Attwood, Stefan Knapp
exaly