Results 31 to 40 of about 1,086,674 (386)
Complex formation of EphB1/Nck/Caskin1 leads to tyrosine phosphorylation and structural changes of the Caskin1 SH3 domain. [PDF]
, 2012 Scaffold proteins have an important role in the regulation of signal propagation. These proteins do not possess any enzymatic activity but can contribute to the formation of multiprotein complexes.
Balázs Annamária +6 more
core +2 more sources
Frontiers in Molecular Biosciences, 2018 Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a variety of secondary metabolites, a subset of which are involved in ...
Anutthaman Parthasarathy +6 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 BackgroundParkinson’s disease (PD) is a common neurodegenerative disorder, accompanied by motor deficits as well as gastrointestinal dysfunctions.
Can Cui +5 more
doaj +1 more source
The Rotational Spectrum of Tyrosine [PDF]
The Journal of Physical Chemistry A, 2015 In this work neutral tyrosine has been generated in the gas phase by laser ablation of solid samples, and its most abundant conformers characterized through their rotational spectra. Their identification has been made by comparison between the experimental and ab initio values of the rotational and quadrupole coupling constants.
Pérez Cuadrado, Cristobal +4 more
openaire +4 more sources
Tyrosine supplementation for phenylketonuria [PDF]
Cochrane Database of Systematic Reviews, 2010 Phenylketonuria is an inherited disease for which the main treatment is the dietary restriction of the amino acid phenylalanine. The diet has to be initiated in the neonatal period to prevent or reduce mental handicap. However, the diet is very restrictive and unpalatable and can be difficult to follow.
Joanne Wildgoose, Diana Webster
openaire +3 more sources
Beilstein Journal of Organic Chemistry, 2015 Amino acids, whether natural, semisynthetic or synthetic, are among the most important and useful chiral building blocks available for organic chemical synthesis.
Tor E. Kristensen
doaj +1 more source
Entropy, 2013 Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide. The industry asserts it is minimally toxic to humans, but here we argue otherwise.
Anthony Samsel, Stephanie Seneff
doaj +1 more source
Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown [PDF]
Scientific Reports 6, Article number: 30245 (2016), 2017 A tri-block nanoparticle (TBN) comprising of an enzymatically cleavable porous gelatin nanocore encapsulated with gefitinib (tyrosine kinase inhibitor (TKI)) and surface functionalized with cetuximab-siRNA conjugate has been synthesized. Targeted delivery of siRNA to undruggable KRAS mutated non-small cell lung cancer cells would sensitize the cells to
arxiv +1 more source
Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines [PDF]
, 2014 This protocol describes a highly reproducible antibody-based method that provides protein level and phosphorylation status information from nanogram quantities of protein cell lysate.
Aspinall-O'Dea, Mark +7 more
core +1 more source
Engineering tyrosine-based electron flow pathways in proteins: The case of aplysia myoglobin [PDF]
, 2012 Tyrosine residues can act as redox cofactors that provide an electron transfer ("hole-hopping") route that enhances the rate of ferryl heme iron reduction by externally added reductants, for example, ascorbate.
Alayash A. I. +39 more
core +1 more source