Results 51 to 60 of about 1,086,674 (386)

Method development and validation for analysis of phenylalanine, 4‐hydroxyphenyllactic acid and 4‐hydroxyphenylpyruvic acid in serum and urine

JIMD Reports, 2022
Alkaptonuria (AKU) is a rare debilitating autosomal recessive disorder of tyrosine (TYR) metabolism which results in a deficiency of the enzyme homogentisate 1,2‐dioxygenase activity.
Andrew T. Hughes, Anna M. Milan, Ella Shweihdi, James Gallagher, Lakshminarayan Ranganath   +4 more
doaj   +1 more source

On the Applicability of Chitosan Oligomers-Amino Acid Conjugate Complexes as Eco-Friendly Fungicides against Grapevine Trunk Pathogens

Agronomy, 2021
In a context in which the incidence and severity of grapevine fungal diseases is increasing as a result of both climate change and modern management culture practices, reducing the excessive use of phytosanitary products in viticulture represents a major
Laura Buzón-Durán, Natalia Langa-Lomba, Vicente González-García, José Casanova-Gascón, Jesús Martín-Gil, Eduardo Pérez-Lebeña, Pablo Martín-Ramos   +6 more
doaj   +1 more source

The nucleotide and partial amino acid sequences of rat fetuin [PDF]

, 1992
Fetuins are among the major plasma proteins, yet their biological role has remained elusive. Here we report the molecular cloning of rat fetuin and the sequence analysis of a full-length clone, RF619 of 1456 bp with an open reading frame of 1056 bp ...
Albrecht G. J., Brown W. M., Cam A., Cayatte A. J., Christie D. L., Cohen P., Colclasure G. C., Coughlin J. P., Davis L. G., Dziegielewska K. M., Dziegielewska K. M., Dziegielewska K. M., Edge A. S. B., Haasemann M., Heijne G., Hortin G., Jones S. E., Kellermann J., Laemmli U. K., Lee C. C., Lewis J. G., Mizuno M., Mollgard K., Muller-Esterl W., Oss C. J., Pedersen K. O., Puck T. T., Rawlings N. D., Rohrlich S. T., Sambrook J., Sanger F., Sbraccia P., Schultze H. E., Strauss E. C., Triffitt J. T., Yang F., Yet M. G.   +36 more
core   +1 more source

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22 [PDF]

Journal of Clinical Investigation, 2016
Inflammasomes form as the result of the intracellular presence of danger-associated molecular patterns and mediate the release of active IL-1β, which influences a variety of inflammatory responses. Excessive inflammasome activation results in severe inflammatory conditions, but physiological IL-1β secretion is necessary for intestinal homeostasis. Here,
Spalinger Marianne, Kasper Stephanie, Gottier Claudia, Lang Silvia, Atrott Kirstin, Vavricka Stephan, Scharl Sylvie, Gutte Peter, Grütter Markus, Beer Hans-Dietmar, Contassot Emmanuel, Chan Andrew, Dai X, Rawlings David, Mair Florian, Becher Burkhard, Frey Isabelle, Raselli Tina, Falk Werner, Fried Michael, Rogler Gerhard, Scharl Michael   +21 more
openaire   +7 more sources

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Frontiers in Public Health, 2023
BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler, John Tyler, Madeline Podaras, Madeline Podaras, Brittany Richardson, Brittany Richardson, Nicole Roeder, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A. Baron, Panayotis K. Thanos, Panayotis K. Thanos   +14 more
doaj   +1 more source

Sampling the protonation states: pH-dependent UV absorption spectrum of a polypeptide dyad [PDF]

, 2017
When a chromophore interacts with titrable molecular sites, the modeling of its photophysical properties requires to take into account all their possible protonation states. We have developed a multi-scale protocol, based on constant-pH molecular dynamics simulations coupled to QM/MM excitation energy calculations, aimed at sampling both the phase ...
arxiv   +1 more source

Comments on the papers recently published by Kalaivani et al [PDF]

J Cryst Growth 440 (2016) 110-112, 2015
We argue that the so-called l lysinium succinate (journal of crystal growth 426 (2015) 135), zinc chloride doped l lysinium succinate (journal of crystal growth 428 (2015) 24), and l threonine phthalate (journal of crystal growth 427 (2015) 29) and sodium acetate doped l tyrosine (spectrochimica acta 136a (2015) 168) are all dubious crystals.
arxiv   +1 more source

A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. [PDF]

, 2012
EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly.
Ataman, Bulent, Bloodgood, Brenda L, Cowan, Christopher W, Greenberg, Michael E, Ho, Hsin-Yi Henry, Malik, Athar N, Robichaux, Michael A, Rubin, Alex A, Sharma, Nikhil, Shokat, Kevan M, Soskis, Michael J, Zhang, Chao, Zieg, Janine   +12 more
core   +1 more source

Exploring the Interaction of Indole-3-Acetonitrile with Neuroblastoma Cells: Understanding the Connection with the Serotonin and Dopamine Pathways

Biomedicines, 2023
Indole-3-acetonitrile, a compound produced by bacteria and plants as a defense and survival signal in response to attacks, has been recently discovered as a metabolite produced by human cancer cells.
Catarina Moura, Ana Salomé Correia, Nuno Vale   +2 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source