Results 261 to 270 of about 438,950 (335)

Mechanisms of resistance to tyrosine kinase inhibitor-targeted therapy and overcoming strategies. [PDF]

MedComm (2020)
Ou X, Gao G, Habaz IA, Wang Y.
europepmc   +1 more source

Acetylcholine- and cyclopiazonic acid-induced relaxation of rat aorta is inhibited by methyl 2',5’-dihydroxycinnamate, but not by herbimycin A. Involvement of tyrosine kinase in endothelial NO formation.

, 1994
Kazuve Imada, Mari Yamaguchi, Tetsuhiro Hisayama, Hideki Moritoki   +3 more
openalex   +1 more source

Research Trends of Tyrosine Kinase Inhibitors in EGFR-Mutated Non-Small Cell Lung Cancer: A Bibliometric Analysis. [PDF]

Drug Des Devel Ther
Chang X, Wang C, Zhang L.
europepmc   +1 more source

The Induction and Characterization of a Potential Rough‐Type Brucella Vaccine Candidate Strain RA343, and Its Safety, Protective Efficacy in Mouse and Guinea Pig Models

Animal Research and One Health, EarlyView.
Brucellosis is a zoonotic disease caused by Brucella spp. which seriously jeopardize the health and safety of animals and human beings. In this study, a genetically stable Brucella rough RA343 strain was obtained by cross‐induction. The virulence and protective efficacy of RA343 were subsequently assessed. Overall, the RA343 strain is a promising novel
Linjiao Li, Guangzhi Zhang, Minghe Liu, Lang Lv, Xiaowei Peng, Yu Feng, Xiaotong Yang, Jiabo Ding, Chunhai Liu, Jianhua Qin, Peng Li, Hui Jiang, Xuezheng Fan   +12 more
wiley   +1 more source

Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune‐regulatory cells in pain is unknown. Our objective was to identify synovial innate immune
Holly T. Philpott, Trevor B. Birmingham, Garth Blackler, J. Daniel Klapak, Alexander J. Knights, Easton C. Farrell, Benoit Fiset, Logan A. Walsh, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, Tristan Maerz, C. Thomas Appleton, on behalf of the WOREO Knee Study Group   +14 more
wiley   +1 more source

Association of tyrosine kinase 2 polymorphisms with susceptibility to microscopic polyangiitis in a Guangxi population. [PDF]

PeerJ
Yang B, Chu L, Feng F, Lu S, Xue C.
europepmc   +1 more source

Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA‐ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA‐ILD discrimination beyond clinical and genetic ...
Austin M. Wheeler, Joshua F. Baker, Thomas R. Riley IV, Tate M. Johnson, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Gail Kerr, Dana P. Ascherman, Paul Monach, Andreas Reimold, Scott Matson, Jill A. Poole, Michael J. Duryee, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +18 more
wiley   +1 more source

Is Autophagy Targeting a Valid Adjuvant Strategy in Conjunction with Tyrosine Kinase Inhibitors? [PDF]

Cancers (Basel)
Elshazly AM, Xu J, Melhem N, Abdulnaby A, Elzahed AA, Saleh T, Gewirtz DA.   +6 more
europepmc   +1 more source

Antifibrotic effects of specific targeting of the 5‐hydroxytryptamine 2B receptor (5‐HT2BR) in murine models and ex vivo models of scleroderma skin

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is a connective tissue disease with fibrotic remodeling of the skin and various internal organs. SSc is associated with the highest case‐specific mortality of all rheumatic autoimmune diseases with limited antifibrotic treatment options.
Thuong Trinh‐Minh, Cuong Tran‐Manh, Andrea‐Hermina Györfi, Nicholas Dickel, Christoph Liebel, Xiang Zhou, Jiucun Wang, Meik Kunz, Helena Arozenius, Lars Pettersson, Sam Lindgren, Christina Wenglén, Jörg H. W. Distler   +12 more
wiley   +1 more source

Cannabinoids as Promising Inhibitors of HER2-Tyrosine Kinase: A Novel Strategy for Targeting HER2-Positive Ovarian Cancer. [PDF]

ACS Omega
Lamtha T, Jongkon N, Lertvanithphol T, Horprathum M, Seetaha S, Choowongkomon K.   +5 more
europepmc   +1 more source