Results 261 to 270 of about 825,078 (353)

Exploring Clinical and Genetic Factors to Optimize the Use of Tyrosine Kinase Inhibitors in Clinical Practice

, 2019
Nancy Gillis
openalex   +2 more sources

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

Advanced Science, EarlyView.
Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang, Yedong Tang, Xueling Zhao, Yu Ni, Hualan Zhou, Enhao Zhang, Gaizhen Li, Han Cai, Yinan Wang, James R. Woodgett, Wenbo Deng, Haibin Wang, Zhongxian Lu, Haili Bao, Shuangbo Kong   +14 more
wiley   +1 more source

Reshape memory T cell landscape in CML patients' blood by tyrosine kinase inhibitors. [PDF]

Caspian J Intern Med
Kareem HA, Ghadi HH.
europepmc   +1 more source

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

Mechanistic Insights into Threonine Tyrosine Kinase Mediated Cell Cycle Regulation in Triple-negative Breast Cancer. [PDF]

Cancer Genomics Proteomics
Tang S, Zheng J, Zhang Y, Zeng LI, Wang J, Zhang S, Chen Y, Yin Q, Zheng X.   +8 more
europepmc   +1 more source

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication

Advanced Science, EarlyView.
A CD169+ macrophage‐targeted immunomodulator (G‐LNP@S‐D) is developed to co‐deliver a SHP2 inhibitor and STING agonist, thereby restoring phagocytic function, enhancing antigen presentation by CD169+ macrophages, and promoting T cell priming to eradicate lymphatic metastasis.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
wiley   +1 more source

Elevated Spleen Tyrosine Kinase in Low-Density Neutrophils During Bacterial Sepsis in a Nonhuman Primate Model. [PDF]

J Infect Dis
Teague HL, Warner S, Platt AP, Stein S, Ramos-Benitez MJ, Ramelli S, Curran S, Lach I, Allen K, Adetola H, Stantliff T, da Cruz RS, Minai M, Kendall H, Vannella KM, Alves DA, Herbert R, Chertow DS, Strich JR.   +18 more
europepmc   +1 more source

Alpha-fetoprotein response predicts treatment outcomes in patients with unresectable hepatocellular carcinoma receiving immune checkpoint inhibitors with or without tyrosine kinase inhibitors or locoregional therapies.

, 2021
Wei‐Fan Hsu, Hung‐Wei Wang, Cheng‐Kuo Chen, Hung‐Chun Lai, Po‐Heng Chuang, Mu‐Hung Tsai, Wen‐Pang Su, Hung‐Yao Chen, Chia‐Sheng Chu, Jen‐Wei Chou, Sheng‐Hung Chen, Tsung-Yu Tsai, Wang‐De Hsiao, Chi‐Chen Lin, Guan‐Tarn Huang, Ming‐Tsan Lin, Cheng‐Yuan Peng   +16 more
openalex   +1 more source

Tyrosine Kinase Domain [PDF]

, 2020
openaire   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source