Results 121 to 130 of about 207,078 (211)

Molecular mechanism of ethanol fermentation inhibition via protein tyrosine nitration of pyruvate decarboxylase by reactive nitrogen species in yeast. [PDF]

Sci Rep, 2022
Eknikom S, Nasuno R, Takagi H.
europepmc   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3868-3881, November 2026.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia

Mediators of Inflammation, 2013
Activation of the N-methyl-D-aspartate receptor (NMDAR) is fundamental in the development of hyperalgesia. Overactivation of this receptor releases superoxide and nitric oxide that, in turn, forms peroxynitrite (PN).
Carolina Muscoli, Concetta Dagostino, Sara Ilari, Filomena Lauro, Micaela Gliozzi, Erlisa Bardhi, Ernesto Palma, Vincenzo Mollace, Daniela Salvemini   +8 more
doaj   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Alzheimer's Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu, Mingmin Pan, Qingling Sun, Guangxin Yue, Tong Lei   +4 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, Volume 31, Issue 11, Page 1077-1090, November 2026.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Phosphatidylinositol 3-kinase is a target for protein tyrosine nitration

, 1998
A major mechanism of injury associated with the production of nitric oxide (NO*) in vivo is due to its diffusion-limited reaction with superoxide to form peroxynitrite, which in turn may cause nitration of protein tyrosine residues.
Boggs, S E, Hellberg, Karina, Hellberg, C B, Lapetina, E G   +3 more
core   +1 more source

Genetic Engineering Efforts to Generate Chlamydomonas Strains for Large‐Scale Biomolecule Production

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
This represents the main aspects relevant to potential industrialization of Chlamydomonas. ABSTRACT Chlamydomonas reinhardtii is an established model microalga. Its easy manipulation, metabolic flexibility and tractable genomes allowed researchers to investigate fundamental processes such as photosynthesis using genetic studies for decades ...
Sofia Inturri, Nicolas Rouhier, Claire Remacle   +2 more
wiley   +1 more source

Towards an In‐Depth Understanding of the Versatile Functions of Silicon in Legumes Under Biotic and Abiotic Stress: Identifying Research Gaps

Journal of Agronomy and Crop Science, Volume 212, Issue 6, November 2026.
ABSTRACT Studies have shown the vital role of silicon (Si) under stress conditions, suggesting it could be used as a basic fertilizer. Collectively, as a strategic approach under biotic and abiotic stress conditions, Si offers a sustainable means to boost legume resilience and productivity, thereby contributing significantly to food security amid ...
Muna A. Abdalla, Katya M. Aguilar Perez, Saad Sulieman, Karl H. Mühling   +3 more
wiley   +1 more source