Results 161 to 170 of about 8,951 (194)
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Enrichment and Detection of Tyrosine‐Nitrated Proteins
Current Protocols in Protein Science, 2012AbstractNitrotyrosine is a post‐translationally modified amino acid with distinctly different properties than tyrosine or any other of the genetically encoded amino acids. Detecting proteins containing nitrotyrosine is the first step towards a better understanding of the role of nitrotyrosine in health and disease.
Dekker, Frank +4 more
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Protein Tyrosine Nitration: Role in Aging
Current Aging Science, 2017Aging is the inevitable fate of all living organisms, but the molecular basis of physiological aging is poorly understood. Oxidative stress is believed to play a key role in the aging process. In addition to Reactive Oxygen Species (ROS), Reactive Nitrogen Species (RNS) are generated during aerobic metabolism in living organisms.
Bulbul, Chakravarti, Deb N, Chakravarti
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Nitration of tyrosine in three cobra neurotoxins
Toxicon, 1976Abstract The curarumimetic snake venom toxins always have a tyrosine residue in the same position in their sequences. This invariant tyrosine in three neurotoxins has been nitrated with tetranitromethane. The toxins were: (1) siamensis 3 of the structural type 71-5 (no. of amino acid residues and disulfides) and with one tyrosine, the main neurotoxin
E, Karlsson, J, Sundelin
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Protein tyrosine nitration in the cell cycle
Biochemical and Biophysical Research Communications, 2011Nitration of tyrosine residues in proteins is associated with cell response to oxidative/nitrosative stress. Tyrosine nitration is relatively low abundant post-translational modification that may affect protein functions. Little is known about the extent of protein tyrosine nitration in cells during progression through the cell cycle.
Min, Jia +2 more
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Nitration of Tyrosine by Hydrogen Peroxide and Nitrite
Free Radical Research, 1995Peroxynitrite anion is a powerful oxidant which can initiate nitration and hydroxylation of aromatic rings. Peroxynitrite can be formed in several ways, e.g. from the reaction of nitric oxide with superoxide or from hydrogen peroxide and nitrite at acidic pH.
T D, Oury +3 more
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Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Chemical Reviews, 2018Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-controlled reaction of the free radicals superoxide (O2•-) and nitric oxide (•NO). In this review, we first analyze the biochemical evidence for the formation of peroxynitrite in vivo and the reactions that lead to it. Then, we describe the principal reactions that
Gerardo Ferrer-Sueta +7 more
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Tetranitromethane as a Nitrating Reagent for Tyrosine and Tyrosine-Containing Peptides and Proteins
Canadian Journal of Biochemistry, 1971After nitration of hemoglobin and ribonuclease with tetranitromethane, the sum of tyrosine and nitrotyrosine accounted for 80% or less of the tyrosyl residues known to be present in these proteins. Reasons for this discrepancy were explored by nitrating tyrosine, glycyltyrosine, and glycyltyrosylglycine.
N D, Boyd, D B, Smith
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Monitoring peptide tyrosine nitration by spectroscopic methods
Amino Acids, 2020Oxidative stress can lead to various derivatives of the tyrosine residue in peptides and proteins. A typical product is 3-nitro-L-tyrosine residue (Nit), which can affect protein behavior during neurodegenerative processes, such as those associated with Alzheimer's and Parkinson's diseases. Surface enhanced Raman spectroscopy (SERS) is a technique with
Petr Niederhafner +5 more
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Protein Tyrosine Phosphorylation and Protein Tyrosine Nitration in Redox Signaling
Antioxidants & Redox Signaling, 2008Reversible phosphorylation of protein tyrosine residues by polypeptide growth factor-receptor protein tyrosine kinases is implicated in the control of fundamental cellular processes including the cell cycle, cell adhesion, and cell survival, as well as cell proliferation and differentiation.
Hugo P, Monteiro +2 more
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