Results 191 to 200 of about 207,078 (211)

Neopterin Derivatives Modulate the Nitration of Tyrosine by Peroxynitrite

Biochemical and Biophysical Research Communications, 1998
The impact of neopterin and 7,8-dihydroneopterin on peroxynitrite-induced nitration of l-tyrosine was studied. Neopterin derivatives and peroxynitrite are formed during immune response. Tyrosine nitration represents one major effect of nitric oxide-mediated cytotoxicity.
B, Widner, G, Baier-Bitterlich, I, Wede, B, Wirleitner, D, Fuchs   +4 more
openaire   +2 more sources

Proteomic Method for Identification of Tyrosine-Nitrated Proteins

2004
Biologic nitration of protein tyrosine (to form 3-nitrotyrosine) is a recently described phenomenon that is associated with many diseases. We have devised a proteomic methodology to identify these modified proteins. This utilizes protein fractionation by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), partial transfer onto polyvinylidene
Kulwant S, Aulak, Thomas, Koeck, John W, Crabb, Dennis J, Stuehr   +3 more
openaire   +2 more sources

Nitration of tyrosine and its effect on DNA hybridization

Biosensors and Bioelectronics, 2018
One major marker of nitrosative stress is the formation of 3-Nitrotyrosine (3-NT) from Tyrosine (Tyr) by adding a nitro group (-NO2) with nitrating agents. Nitration of Tyr often causes loss of protein activity and is linked with many diseases. In this article, we detect 3-NT and discriminate it from Tyr with Differential Pulse Voltammetry (DPV) as it ...
Topkaya, Seda Nur, Ozyurt, Vasfiye Hazal, Cetin, Arif E., Otles, Semih   +3 more
openaire   +2 more sources

Identification of tyrosine nitration in UCH‐L1 and GAPDH

ELECTROPHORESIS, 2011
AbstractProtein tyrosine nitration is a post‐translational modification commonly used as a marker of cellular oxidative stress associated with numerous pathophysiological conditions. We focused on ubiquitin carboxyl terminal hydrolase‐L1 (UCH‐L1) and glyceraldehyde‐3‐phosphate (GAPDH) which are high‐abundant brain proteins that have been identified to ...
Joy D, Guingab-Cagmat, Stanley M, Stevens, Mary V, Ratliff, Zhiqun, Zhang, Mark S, Gold, John, Anagli, Kevin K W, Wang, Firas H, Kobeissy   +7 more
openaire   +2 more sources

Protein Tyrosine Nitration in Hyperammonemia and Hepatic Encephalopathy

Metabolic Brain Disease, 2005
Hepatic encephalopathy is seen as a clinical manifestation of a chronic low grade cerebral edema, which is thought to trigger disturbances of astrocyte function, glioneuronal communication, and finally HE symptoms. In cultured astrocytes, hypoosmotic swelling triggers a rapid oxidative stress response, which involves the action of NADPH oxidase ...
Dieter, Häussinger, Boris, Görg, Roland, Reinehr, Freimut, Schliess   +3 more
openaire   +2 more sources

Peroxynitrite and protein tyrosine nitration of prostacyclin synthase

Prostaglandins & Other Lipid Mediators, 2007
When working on the regulation of prostacyclin synthase (PGIS), we found that PGIS was selectively inhibited by peroxynitrite (ONOO-), a potent oxidant formed by the combination of superoxide anion and nitric oxide (NO) at a rate of diffusion-controlled. None of the cellular antioxidants studied (i.e.
openaire   +2 more sources

Protein tyrosine nitration and peroxynitrite

The FASEB Journal, 2002
William M. Deen, Steven R. Tannenbaum, Joseph S. Beckman   +2 more
openaire   +2 more sources

Quantitation and localization of tyrosine nitration in proteins

2002
Patrick S Y, Wong, Albert, van der Vliet
openaire   +2 more sources

Reversible Inhibition of Mammalian Glutamine Synthetase by Tyrosine Nitration

FEBS Letters, 2007
Dieter Häussinger, Freimut Schliess, Tilman Grune   +2 more
exaly  

Factors Influencing Protein Tyrosine Nitration—Structure-Based Predictive Models

Free Radical Biology and Medicine, 2011
Vasily A Yakovlev, Glen E. Kellogg, Ross B Mikkelsen   +2 more
exaly