Results 61 to 70 of about 205,532 (202)

Lactation defect in a widely used MMTV-Cre transgenic line of mice. [PDF]

PLoS ONE, 2011
MMTV-Cre mouse lines have played important roles in our understanding about the functions of numerous genes in mouse mammary epithelial cells during mammary gland development and tumorigenesis. However, numerous studies have not included MMTV-Cre mice as
Taichang Yuan, Yongping Wang, Lily Pao, Steve M Anderson, Haihua Gu   +4 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Pf-Int is a tyrosine recombinase.

, 2012
A) Schematic representation of domain organization of Pf-Int. The integrase is 490 amino acids long and is predicted to have two DNA-binding domains, the Arm binding domain (117–156 aa residues) and the core-binding domain (192–490 aa residues). The core
Christophe Thomas (130030), Genevieve Paisley (130035), Claire Faltermeier (130040), Jose-Juan Lopez-Rubio (106848), Christine Scheidig-Benatar (130021), Deshmukh N. Gopaul (130052), Mehdi Ghorbal (130016), Melanie Liu (130045), Salma Bouizem (130025), Artur Scherf (7392)   +9 more
core   +1 more source

Data_Sheet_1_In vitro DNA Inversions Mediated by the PsrA Site-Specific Tyrosine Recombinase of Streptococcus pneumoniae.DOCX

, 2020
Site-specific recombination is a DNA breaking and reconstructing process that plays important roles in various cellular pathways for both prokaryotes and eukaryotes. This process requires a site-specific recombinase and direct or inverted repeats.
Jingwen Li (314020), Sofía Ruiz-Cruz (8597100), Jing-Ren Zhang (271032), Alicia Bravo (4886896), Manuel Espinosa (25471), Juanjuan Wang (1807810)   +5 more
core   +1 more source

In vitro site‐specific recombination mediated by the tyrosine recombinase XerA of Thermoplasma acidophilum [PDF]

Genes to Cells, 2017
In organisms with circular chromosomes, such as bacteria and archaea, an odd number of homologous recombination events can generate a chromosome dimer. Such chromosome dimers cannot be segregated unless they are converted to monomers before cell division.
Minji Jo, Yasuto Murayama, Yasuhiro Tsutsui, Hiroshi Iwasaki   +3 more
openaire   +2 more sources

Operant self-stimulation of dopamine neurons in the substantia nigra. [PDF]

PLoS ONE, 2013
We examined the contribution of the nigrostriatal DA system to instrumental learning and behavior using optogenetics in awake, behaving mice. Using Cre-inducible channelrhodopsin-2 (ChR2) in mice expressing Cre recombinase driven by the tyrosine ...
Mark A Rossi, Tatyana Sukharnikova, Volodya Y Hayrapetyan, Lucie Yang, Henry H Yin   +4 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Recombinase-Mediated Cassette Exchange (RMCE)-in Reporter Cell Lines as an Alternative to the Flp-in System - Table 1

, 2016
Recombinase-Mediated Cassette Exchange (RMCE)-in Reporter Cell Lines as an Alternative to the Flp-in System - Table
Morten M. Callesen (664993), Ernst-Martin Füchtbauer (283863), Martin F. Berthelsen (3067749), Jannik E. Jakobsen (3067755), Annette C. Füchtbauer (3067752), Sira Lund (3067746)   +5 more
core   +1 more source

Image_1_In vitro DNA Inversions Mediated by the PsrA Site-Specific Tyrosine Recombinase of Streptococcus pneumoniae.TIF

, 2020
Site-specific recombination is a DNA breaking and reconstructing process that plays important roles in various cellular pathways for both prokaryotes and eukaryotes. This process requires a site-specific recombinase and direct or inverted repeats.
Jingwen Li (314020), Sofía Ruiz-Cruz (8597100), Jing-Ren Zhang (271032), Alicia Bravo (4886896), Manuel Espinosa (25471), Juanjuan Wang (1807810)   +5 more
core   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source