Results 181 to 190 of about 4,897 (216)

Engineering spacer specificity of the Cre/loxP system. [PDF]

Nucleic Acids Res
Hoersten J, Ruiz-Gómez G, Paszkowski-Rogacz M, Gilioli G, Guillem-Gloria PM, Lansing F, Pisabarro MT, Buchholz F.   +7 more
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Structural basis of directionality control in large serine integrases

Shin H, Pigli Y, Peña Reyes T, Fuller JR, Olorunniji FJ, Rice PA.   +5 more
europepmc   +1 more source

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Cre Recombinase and Other Tyrosine Recombinases

Chemical Reviews, 2016
Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the predictable modification of genomes as they enable precise genome editing in heterologous hosts. These enzymes are ubiquitous in eubacteria, prevalent in archaea and temperate phages, present in certain yeast strains, but barely found in higher eukaryotes.
Gretchen, Meinke, Andrew, Bohm, Joachim, Hauber, M Teresa, Pisabarro, Frank, Buchholz   +4 more
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DIRS-1 and the other tyrosine recombinase retrotransposons

Cytogenetic and Genome Research, 2005
DIRS-1 is a retroelement from the slime mold <i>Dictyostelium discoideum</i>. Until recently only two related retrotransposons had been described: PAT from the nematode <i>Panagrellus redivivus</i> and <i>Prt1</i> from the zygomycete fungus <i>Phycomyces blakesleeanus</i>.
R T M, Poulter, T J D, Goodwin
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Peptide inhibitors of DNA cleavage by tyrosine recombinases and topoisomerases

Journal of Molecular Biology, 2000
The study of biochemical pathways requires the isolation and characterization of each and every intermediate in the pathway. For the site-specific recombination reactions catalyzed by the bacteriophage lambda tyrosine recombinase integrase (Int), this has been difficult because of the high level of efficiency of the reaction, the highly reversible ...
M, Klemm, C, Cheng, G, Cassell, S, Shuman, A M, Segall   +4 more
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Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus

genesis, 2004
AbstractCatecholaminergic neurons are affected in several neurological and psychiatric diseases. Tyrosine hydroxylase (TH) is the first, rate‐limiting enzyme in catecholamine synthesis. We report a knockin mouse expressing Cre‐recombinase from the 3′‐untranslated region of the endogenous Th gene by means of an internal ribosomal entry sequence (IRES ...
Jonas, Lindeberg, Dmitry, Usoskin, Henrik, Bengtsson, Anna, Gustafsson, Annika, Kylberg, Stine, Söderström, Ted, Ebendal   +6 more
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Strand Selection by the Tyrosine Recombinases

2005
Publisher Summary This chapter focuses on four tyrosine recombinases for which there is a wealth of biochemical and structural data. This chapter reviews the biochemical and structural findings for each of these enzymes. This chapter also examines the factors that influence strand selection and consider the possible function of strand selection in ...
Linda, Lee, Paul D, Sadowski
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Dual Recombinase-Mediated Cassette Exchange by Tyrosine Site-Specific Recombinases

2017
Recombinase-mediated cassette exchange, or RMCE, is a genome engineering tool that can be used to swap DNA fragments of interest between two DNA molecules. In a variation of RMCE, called dual RMCE, the exchange of DNA fragments is mediated by two recombinases in contrast to one recombinase in the classic RMCE reaction.
Eugenia, Voziyanova, Rachelle P, Anderson, Yuri, Voziyanov   +2 more
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Cryptons: a group of tyrosine-recombinase-encoding DNA transposons from pathogenic fungi

Microbiology, 2003
A new group of transposable elements, which the authors have named cryptons, was detected in several pathogenic fungi, including the basidiomyceteCryptococcus neoformans, and the ascomycetesCoccidioides posadasiiandHistoplasma capsulatum. These elements are unlike any previously described transposons. An archetypal member of the group, cryptonCn1, is 4 
Timothy J D, Goodwin, Margaret I, Butler, Russell T M, Poulter   +2 more
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The VIPER elements of trypanosomes constitute a novel group of tyrosine recombinase-enconding retrotransposons

Molecular and Biochemical Parasitology, 2006
VIPER was initially characterized as a 2326bp LTR-like retroelement associated to SIRE, a short interspersed repetitive element specific of Trypanosoma cruzi. It carried a single ORF that coded for a putative reverse transcriptase-RNAse H protein, suggesting that it could be a truncated copy of a longer retroelement. Herein we report the identification
Hernan A, Lorenzi, German, Robledo, Mariano J, Levin   +2 more
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