Results 51 to 60 of about 12,575 (173)

Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes

Cell Reports, 2017
Summary: Pat1 RNA-binding proteins, enriched in processing bodies (P bodies), are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer.
Caroline Vindry, Aline Marnef, Helen Broomhead, Laure Twyffels, Sevim Ozgur, Georg Stoecklin, Miriam Llorian, Christopher W. Smith, Juan Mata, Dominique Weil, Nancy Standart   +10 more
doaj   +1 more source

Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila

eLife, 2018
Transcription-translation feedback loops that comprise eukaryotic circadian clocks rely upon temporal delays that separate the phase of active transcription of clock genes, such as Drosophila period (per) and timeless (tim), from negative feedback by the
Iryna Shakhmantsir, Soumyashant Nayak, Gregory R Grant, Amita Sehgal   +3 more
doaj   +1 more source

Molecular architecture of the human U4/U6.U5 tri-snRNP

Science, 2016
A human spliceosomal subcomplex The spliceosome is an RNA and protein molecular machine that cuts out introns from messenger RNAs. Agafonov et al. used cryo-electron microscopy to determine the structure of the largest intermediate subcomplex on the assembly pathway for the ...
Agafonov, D., Kastner, B., Dybkov, O., Hofele, R., Liu, W., Urlaub, H., Lührmann, R., Stark, H.   +7 more
openaire   +4 more sources

Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants

Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.
ABSTRACT Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract, where oxidative stress is a significant contributing factor to its pathogenesis. This study utilized multi‐omics data, including RNA sequencing from the GSE216447 dataset and three genome‐wide association studies (GWAS) datasets (ieu‐a‐10, ieu‐a‐11, ieu‐a ...
Juan Yang, Lida Zhang, Xiaqing Wang, Yuxiu Yang   +3 more
wiley   +1 more source

Anti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity

Clinical Immunology and Immunopathology, 1996
We surveyed for autoantibodies to the U small nuclear ribonucleoproteins (snRNPs) in sera from 1171 patients with various connective tissue diseases by immunoprecipitation assay. We found serum, termed LaJ, which principally recognized the U5 snRNP from one patient with systemic sclerosis-polymyositis overlap syndrome. Anti-LaJ serum immunoprecipitated
Y, Okano, I N, Targoff, C V, Oddis, T, Fujii, M, Kuwana, K, Tsuzaka, M, Hirakata, T, Mimori, J, Craft, T A, Medsger   +9 more
openaire   +2 more sources

Hemoglobin Digestion Genes Are Conserved in Lizard‐Infective Plasmodium Species With Different Host Cellular Niches

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Despite their evolutionary relatedness to malaria parasites that infect humans, wildlife Plasmodium—particularly those that infect birds and lizards—are understudied, leaving their vast genetic diversity to be explored. By assembling parasite transcriptomes from Plasmodium‐infected lizard blood, we provide the first evidence that lizard‐infective ...
Sarah J. Pangburn, Janus Borner, Sidhanth Misra, Jessica Zavalunova, Susan L. Perkins   +4 more
wiley   +1 more source

prp8 mutations that cause human Retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast

Nature Structural &Molecular Biology, 2007
Prp8 protein (Prp8p) is a highly conserved pre-mRNA splicing factor and a component of spliceosomal U5 small nuclear ribonucleoproteins (snRNPs). Although it is ubiquitously expressed, mutations in the C terminus of human Prp8p cause the retina-specific ...
Kum-Loong Boon, Kum-Loong Boon, R. Grainger, P. Ehsani, J. Barrass, Tatsiana Auchynnikava, C. Inglehearn, J. Beggs   +7 more
semanticscholar   +1 more source

Pathogen‐Induced Shifts in Alternative Splicing Shaping Plant Defense

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
ABSTRACT Plant immune responses comprise a highly coordinated and dynamic defense network that enables the recognition and containment of diverse microbial pathogens. Alternative splicing (AS), a critical post‐transcriptional regulatory mechanism that generates multiple mRNA isoforms from a single pre‐mRNA precursor, substantially enhances proteomic ...
Zijing Li, Mojing Zhang, Muhammad Aamir Khan, Muhammad Ali   +3 more
wiley   +1 more source

Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA

eLife, 2013
Eukaryotes have two types of spliceosomes, comprised of either major (U1, U2, U4, U5, U6) or minor (U11, U12, U4atac, U6atac; <1%) snRNPs. The high conservation of minor introns, typically one amidst many major introns in several hundred genes ...
Ihab Younis, Kimberly Dittmar, Wei Wang, Shawn W Foley, Michael G Berg, Karen Y Hu, Zhi Wei, Lili Wan, Gideon Dreyfuss   +8 more
doaj   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source