, 2008 Das Spleißen der prä-mRNA wird von einer makromolekularen Maschine, dem Spleißosom katalysiert. Das Spleißosom wird schrittweise aus den kleinen nukleären Ribonukleoprotein-Partikeln, den sogenannten U1, U2, U5
Häcker, Irina
core +1 more source
Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy [PDF]
, 2012 This work was funded by the Wellcome Trust (grant ID WT078810MA)It is becoming increasingly clear that defects in RNA metabolism can lead to disease. Spinal muscular atrophy (SMA), a leading genetic cause of infant mortality, results from insufficient ...
Clelland, Allyson Kara +2 more
core +1 more source
Advanced ScienceBiomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled‐coil (WAC) is localized to nuclear speckles via its WW ...
Jiahe Wang +13 more
doaj +1 more source
AtSNU13 modulates pre-mRNA splicing of RBOHD and ALD1 to regulate plant immunity
BMC BiologyPre-mRNA splicing is a significant step for post-transcriptional modifications and functions in a wide range of physiological processes in plants. Human NHP2L binds to U4 snRNA during spliceosome assembly; it is involved in RNA splicing and mediates the ...
Yanke Jiang +8 more
doaj +1 more source
Transcriptomic analysis of tobacco flowering regulated by the BdFKF1 gene in Brachypodium distachyon
Guangxi ZhiwuFKF1 is known to be a blue light-responsive gene and an important factor in regulating plant flowering through the photoperiod pathway. To explore the molecular mechanism of BdFKF1 gene in regulating flowering in tobacco plants through the photoperiod ...
YANG Longjiao1, LI Yajiao2, CHEN Xi2, MA Peijie2, LUO Wenju1, CHEN Caijun2, CHEN Ying2, LIU Xiaoxia2, WANG Xiaoli 2*
doaj +1 more source
Reovirus μ2 protein modulates host cell alternative splicing by reducing protein levels of U5 snRNP core components. [PDF]
Nucleic Acids Res, 2022 Boudreault S +5 more
europepmc +1 more source
, 2005 Daten aus two-hybrid-Versuchen erlaubten es mir, Regionen zu definieren, über die die Proteine 220K, 200K und 116K miteinander interagieren.
Liu, Sunbin
core +1 more source
Investigation into the Saccharomyces cerevisiae U5 snRNP, a core spliceosome component [PDF]
, 2011 The U5 snRNP is a major component of the yeast spliceosome, being part of the U4/U6.U5 tri-snRNP, the precatalytic spliceosome and the catalytically activated spliceosome.
O'Keefe, Raymond, Nancollis, Verity
core
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6 center dot U5 tri-snRNP formation and pre-mRNA splicing [PDF]
, 2002 In each round of nuclear pre-mRNA splicing, the U4/ U6.U5 tri- snRNP must be assembled from U4/U6 and U5 snRNPs, a reaction that is at present poorly understood.
Makarova, O. +4 more
core +1 more source
Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae [PDF]
, 2001 We have purified the yeast U5 and U6 pre-mRNA splicing small nuclear ribonucleoproteins (snRNPs) by affinity chromatography and analyzed the associated polypeptides by mass spectrometry. The yeast U5 snRNP is composed of the two variants of U5 snRNA, six
Lee, Terry D. +6 more
core