Results 61 to 70 of about 12,575 (173)

Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.

Genes & Development, 1992
We have used a site-specific cross-linking strategy to identify RNA and protein factors that interact with the 5' splice site region during mammalian pre-mRNA splicing.
Jacqueline R. Wyatt, Erik J. Sonthe imer, Joan A. Steitz   +2 more
semanticscholar   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Anti-U5 snRNP antibody as a possible serological marker for scleroderma-polymyositis overlap [PDF]

Rheumatology, 2002
To determine the prevalence of the anti-U5 small nuclear ribonucleoprotein (snRNP) antibody in patients with systemic sclerosis.Sera from 281 patients with systemic sclerosis, including 10 patients with overlapping polymyositis, were assayed using RNA immunoprecipitation and protein immunoprecipitation.Only one serum sample showed precipitation of U5 ...
M, Kubo, H, Ihn, M, Kuwana, Y, Asano, T, Tamaki, K, Yamane, K, Tamaki   +6 more
openaire   +2 more sources

Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish

Journal of Ophthalmology, 2015
Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200) gene is a fundamental component for precursor message RNA (pre-mRNA) splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP).
Yuan Liu, Xue Chen, Bing Qin, Kanxing Zhao, Qingshun Zhao, Jonathan P. Staley, Chen Zhao   +6 more
doaj   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Structural investigation of human U6 snRNA recognition by spliceosomal recycling factor SART3 RNA recognition motifs

The FEBS Journal, Volume 293, Issue 5, Page 1323-1340, March 2026.
Human SART3 has two RRM domains to engage with U6 snRNA for spliceosome recycling. This study reports solution structures of SART3 RRM domains and investigates the interaction between RRM and U6 snRNA. SART3 binds to the asymmetric bulge of U6 snRNA as a dimer via conserved positively charged surfaces.
Iktae Kim, Kyeong‐Mi Bang, So Young An, Changkon Park, Ji‐Yeon Shin, Youngim Kim, Hyun Kyu Song, Jeong‐Yong Suh, Nak‐Kyoon Kim   +8 more
wiley   +1 more source

A Novel N‐Terminal PRPF6 Variant in Autosomal Dominant Retinitis Pigmentosa

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT This report identifies the first N‐terminal PRPF6 variant (c.514C>T) as a cause of autosomal dominant Retinitis Pigmentosa. This novel variant is associated with progressive peripheral vision loss but notably preserved central visual acuity, suggesting a distinct phenotypic expression compared to C‐terminal variants.
Na Li, Yalong Dang
wiley   +1 more source

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Regulation of the Neurospora Circadian Clock by the Spliceosome Component PRP5

G3: Genes, Genomes, Genetics, 2019
Increasing evidence has pointed to the connection between pre-mRNA splicing and the circadian clock; however, the underlying mechanisms of this connection remain largely elusive.
Huan Ma, Lin Zhang, Xinyang Yu, Yufeng Wan, Dongni Wang, Weirui Shi, Meiyan Huang, Manhao Xu, Enze Shen, Menghan Gao, Jinhu Guo   +10 more
doaj   +1 more source

snoFlake: A network model for snoRNA–RBP complexes reveals SNORD22 as a U5 snRNP-associated splicing regulator

bioRxiv
Small nucleolar RNAs (snoRNAs) are canonically viewed as stable components of ribonucleoprotein complexes dedicated to RNA modification. Here, we developed snoFlake, a snoRNA-centric interaction network integrating physical and functional associations ...
K.S. Song, Marianne Cyr, Laurence Faucher-Giguère, Bernice Yeo, Vivian Kaiyan Seow, Gabrielle Deschamps-Francoeur, S. Abou Elela, Michelle S. Scott   +7 more
semanticscholar   +1 more source