Results 31 to 40 of about 15,914 (183)

ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

Molecules, 2014
2-Acetylpyridine acetylhydrazone (H2AcMe), 2-benzoylpyridine acetylhydrazone (H2BzMe) and complexes [Cu(H2AcMe)Cl2] (1) and [Cu(H2BzMe)Cl2] (2) were assayed for their cytotoxicity against wild type p53 U87 and mutant p53 T98 glioma cells, and against MRC-
Angel A. Recio Despaigne, Jeferson G. Da Silva, Pryscila R. da Costa, Raquel G. dos Santos, Heloisa Beraldo   +4 more
doaj   +1 more source

Proton beam irradiation stimulates migration and invasion of human U87 malignant glioma cells [PDF]

Journal of Radiation Research, 2013
Migration and invasion of malignant glioma play a major role in tumor progression and can be increased by low doses of gamma or X-ray irradiation, especially when the migrated tumor cells are located at a distance from the main tumor mass or postoperative cavity and are irradiated in fractions.
Zaboronok, Alexander, Isobe, Tomonori, Yamamoto, Tetsuya, Sato, Eisuke, Takada, Kenta, Sakae, Takeji, Tsurushima, Hideo, Matsumura, Akira   +7 more
openaire   +2 more sources

Nanoprodrugs of NSAIDs Inhibit the Growth of U87‐MG Glioma Cells

Journal of Nanomaterials, 2010
Several recent reports have demonstrated that nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the growth of various malignant cells suggesting their application as anticancer agents. In this study, we prepared six nanometer‐sized prodrugs (nanoprodrugs) of NSAIDs, ibuprofen, indomethacin, and naproxen through the spontaneous emulsification ...
Bong-Seop Lee, Xiangpeng Yuan, Qijin Xu, Minhee K. Ko, Aruna K. Nalla, Ilana Frankiel, Talia Shear, Keith L. Black, John S. Yu   +8 more
openaire   +1 more source

A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway

Acta Biochimica et Biophysica Sinica, 2023
Glioma is characterized by rapid cell proliferation, aggressive invasion, altered apoptosis and a poor prognosis. β-Sitosterol, a kind of phytosterol, has been shown to possess anticancer activities. Our current study aims to investigate the effects of β-
Xie Yufang, Chen Zhijian, Li Shuang, Yan Meijuan, He Wenjun, Li Li, Si Junqiang, Wang Yan, Li Xinzhi, Ma Ketao   +9 more
doaj   +1 more source

MicroRNA-128 promotes cell-cell adhesion in U87 glioma cells via regulation of EphB2

Oncology Reports, 2013
MicroRNAs (miRNAs) are small, non-coding RNAs which regulate gene expression at the post-transcriptional level. Abnormal expression of miRNAs occurs frequently in human tumors. Despite the fact that reduced expression of miR-128 has been observed in glioma tissues and cells, the role of miR-128 in tumors has not been fully characterized. In the present
Lina, Lin, Xulin, Chen, Xuelin, Peng, Jianwen, Zhou, Hsiang-Fu, Kung, Marie C, Lin, Songshan, Jiang   +6 more
openaire   +3 more sources

Canstatin represses glioma growth by inhibiting formation of VM-like structures

Translational Neuroscience, 2021
Vasculogenic mimicry (VM) is different from classical tumor angiogenesis and does not depend on endothelial cells. VM is closely related to the prognosis of various cancers. Canstatin was first identified as an endogenous angiogenesis inhibitor.
Ma Yuqiang, Wu Tao, Zhou Houjie, He Guilu, Li Yifei, Wang Bocheng, Guo Qiang, Chen Baodong, Li Weiping   +8 more
doaj   +1 more source

Neuronal Differentiation of Human Glioma Cells Induced by Parthenolide Under In Vitro Conditions

Biomedicines
Objective: Previous drug repositioning studies have suggested that parthenolide may be a differentiation-inducing agent for glioma cells. This study aimed to experimentally verify the neuronal differentiation-inducing effects and proliferative impact of ...
Zhaoqi Tang, Chang Cao, Weiwei Tang, Yanrong Ye, Zhenhui Chen, Yun Shen   +5 more
doaj   +1 more source

Isogambogenic Acid Inhibits the Growth of Glioma Through Activation of the AMPK-mTOR Pathway

Cellular Physiology and Biochemistry, 2017
Background/Aims: Glioma is the most devastating cancer in the brain and has a poor prognosis in adults. Therefore, there is a critical need for novel therapeutic strategies for the management of glioma patients.
Wenyang Zhao, Fei Peng, Mengting Shu, Huailei Liu, Xu Hou, Xiaoxiong Wang, Junyi Ye, Boxian Zhao, Kaikai Wang, Chen Zhong, Linmeng Xue, Ming Gao, Yaohua Liu, Shiguang Zhao   +13 more
doaj   +1 more source

Combination of Caffeic Acid Phenethyl Ester and Crocin Realign Potential Molecular Markers in U87-MG Glioma Cells

Current Therapeutic Research, 2023
: Background: Glial tumors are the most common primary malignant central nervous system tumors. They are hard to treat, not only because of the deregulation in multiple pathways but also because they are not contained in a well-defined mass with clear ...
Ashaq Hussain Mir, PhD, Mir Khurshid Iqbal, PhD, Mujeeb Zafar Banday, PhD, Henah Mehraj Balkhi, PhD, Ehtishamul Haq, PhD   +4 more
doaj   +1 more source

Two‐Photon Polymerized Microvascular Environments for Multicellular Modeling of the Blood–Brain Tumor Barrier

Advanced Materials Technologies, EarlyView.
Modeling the blood–brain tumor barrier is challenging due to complex interactions between brain microvasculature and glioma cells. We present two‐photon polymerized 3D micro‐porous capillary‐like structures that support endothelial alignment, cytoskeletal organization, and pericyte‐endothelial‐glioma tri‐cultures.
Nastaran Barin, Sayba Z. Chowdhury, Maurice de Wit, Rania Head, Kiki Bals, Erwin Brosens, Marvin M. van Luijn, Hayri E. Balcioglu, Angelo Accardo, Pim J. French   +9 more
wiley   +1 more source