Results 91 to 100 of about 60,621 (296)
Journal of Lipid Research, 1991 Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-CoA reductase, or cholestyramine, followed by a period of combined treatment with both drugs.
PG Elmberger +7 more
doaj
Multi-scale Molecular Simulations on Respiratory Complex I [PDF]
Chemical Biology No. 5 (2018), 2019 Complex I (NADH:ubiquinone oxidoreductase) is a redox-driven proton pump that powers synthesis of adenosine triphosphate (ATP) and active transport in most organisms. This gigantic enzyme reduces quinone (Q) to quinol (QH2) in its hydrophilic domain, and transduces the released free energy into pumping of protons across its membrane domain, up to ca ...
arxiv
Genome scale metabolic modeling reveals the metabolic potential of three Type II methanotrophs of the genus Methylocystis [PDF]
, 2019 Producción CientíficaGenome Scale Metabolic Models (GSMMs) of the recently sequenced Methylocystis hirsuta and two other methanotrophs from the genus Methylocystis have been reconstructed.
Bordel Velasco, Sergio +5 more
core +2 more sources
Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li +9 more
wiley +1 more source
Coenzyme Q10: Clinical Applications in Cardiovascular Diseases
Antioxidants, 2020 Coenzyme Q10 (CoQ10) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms.
Alma Martelli +3 more
doaj +1 more source
Quantum coherent contributions in biological electron transfer [PDF]
arXiv, 2011 Many biological electron transfer (ET) reactions are mediated by metal centres in proteins. NADH:ubiquinone oxidoreductase (complex I) contains an intramolecular chain of seven iron-sulphur (FeS) clusters, one of the longest chains of metal centres in biology and a test case for physical models of intramolecular ET.
arxiv
Specific interaction between protein and ubiquinone in succinate-ubiquinone reductase.
Journal of Biological Chemistry, 1982 The lack of ubiquinone in the isolated succinate-ubiquinone reductase (Complex II) and in some preparations of ubiquinone-binding protein (QPs) has caused some concern about the nature of interaction between ubiquinone and QPs. When a low concentration of radioactively labeled ubiquinone derivative in dilute detergent solution was incubated with ...
Chang-An Yu, Linda Yu
openaire +3 more sources
Molecular Nutrition &Food Research, EarlyView.In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang +7 more
wiley +1 more source
Cryo-EM structure of respiratory complex I at work
eLife, 2018 Mitochondrial complex I has a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis.
Kristian Parey +7 more
doaj +1 more source
Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism
Antioxidants, 2020 A lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q10 (CoQ10) has resulted in some manufacturers’ making incorrect claims regarding the bioavailability of their CoQ10 supplements, with potential ...
David Mantle, Alex Dybring
doaj +1 more source