Results 71 to 80 of about 63,603 (255)

Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection [PDF]

, 2005
We describe a method for the determination of the two major urinary metabolites of vitamin K as the methyl esters of their agyclone structures, 2-methyl-3-(3-3-carboxymethylpropyl)-1,4-naphthoquinone (5C-side-chain metabolite) and 2-methyl-3-(5-carboxy-3-
Edwards, C, Harrington, DJ, Hodges, SJ, Savidge, GF, Shearer, MJ, Soper, R   +5 more
core   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

Coenzyme Q₁₀: Clinical Applications in Cardiovascular Diseases

Antioxidants, 2020
Coenzyme Q10 (CoQ10) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms.
Alma Martelli, Lara Testai, Alessandro Colletti, Arrigo F. G. Cicero   +3 more
doaj   +1 more source

Ubiquinone and related compounds. XXXVIII. Biological oxidation of ubiquinone.

Chemical and Pharmaceutical Bulletin, 1985
Ubiquinone-2 (1) was oxidized to 6-[7-carboxy-3-methyl- (2E, 6E)-2, 6-octadienyl]-2, 3-dimethoxy-5-methyl-1, 4-benzoquinone (2) and 6-[6, 7-dihydroxy-3, 7-dimethyl- (E)-2-octenyl]-2, 3-dimethoxy-5-methyl-1, 4-benzoquinone (3) by the 6000×g supernatant of guinea-pig liver homogenate in the presence of nicotinamide-adenine dinucleotide (NAD)- and ...
HIROSHI MORIMOTO, KUNIKO KURIMOTO, ISUKE IMADA   +2 more
openaire   +2 more sources

Elasticity sampling links thermodynamics to metabolic control

, 2013
Metabolic networks can be turned into kinetic models in a predefined steady state by sampling the reaction elasticities in this state. Elasticities for many reversible rate laws can be computed from the reaction Gibbs free energies, which are determined ...
Liebermeister, Wolfram
core   +2 more sources

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source

Synthesis of ubiquinone Q10 (Co Q10) from natural tobacco leaves

Results in Chemistry
The present research work is aimed to develop a methodology for the synthesis of Ubiquinone Q10 (CoQ10) from the natural tobacco leaves (Nicotiana tabacum L).
Venkata Manikya Kumar Ajjarapu
doaj   +1 more source

Bioavailability of Coenzyme Q₁₀: An Overview of the Absorption Process and Subsequent Metabolism

Antioxidants, 2020
A lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q10 (CoQ10) has resulted in some manufacturers’ making incorrect claims regarding the bioavailability of their CoQ10 supplements, with potential ...
David Mantle, Alex Dybring
doaj   +1 more source

Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria [PDF]

, 2018
Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is unclear.
Díaz Moreno, Irene, Díaz Quintana, Antonio Jesús, Elena-Real, Carlos A., García Mauriño, Sofía M., González Arzola, Katiuska, Guerra Castellano, Alejandra, Pérez Mejías, Gonzalo, Rosa Acosta, Miguel Ángel de la   +7 more
core   +1 more source

Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial

Antioxidants
Cardiac surgery-related acute kidney injury (CS-AKI) is a decrease in kidney function after open-heart surgery, affecting up to 50% of patients. The pathophysiology of CS-AKI involves ischemia–reperfusion injury, inflammation, and oxidative stress ...
Hrvoje Vučemilović, Ruben Kovač, Lada Stanišić, Ana Sanader Vučemilović, Dina Mrčela, Benjamin Benzon, Mladen Carev   +6 more
doaj   +1 more source