Results 91 to 100 of about 63,603 (255)

Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood

Neurobiology of Disease, 2012
PDSS2 is a gene that encodes one of the two subunits of trans-prenyl diphosphate synthase that is essential for ubiquinone biosynthesis. It is known that mutations in PDSS2 can cause primary ubiquinone deficiency in humans and a similar disease in mice ...
Song Lu, Lin-Yu Lu, Meng-Fei Liu, Qiu-Ju Yuan, Mai-Har Sham, Xin-Yuan Guan, Jian-Dong Huang   +6 more
doaj   +1 more source

Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene [PDF]

, 2001
The gene for the single subunit, rotenone-insensitive, and flavone-sensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae (NDI1) can completely restore the NADH dehydrogenase activity in mutant human cells that lack the essential ...
Attardi, Giuseppe, Bai, Yidong, Chan, Elisa, Chomyn, Anne, Hájek, Petr, Matsuno-Yagi, Akemi, Seo, Byoung Boo, Yagi, Takao   +7 more
core   +1 more source

Fungal disease management in cotton using plant protection products: An Australian perspective

Pest Management Science, EarlyView.
Cotton disease management requires evidence‐driven use of plant protection products. Progress hinges on integrating chemistry, diagnostics, stewardship and sustainability to build resilient production systems. Abstract Cotton production faces persistent challenges from pathogens that compromise plant establishment, yield, and fibre quality.
Noel L Knight, Linda J Smith, Sambasivam Periyannan, Levente Kiss   +3 more
wiley   +1 more source

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis [PDF]

, 2013
Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin,
Galley, H. F., Lowes, D. A., Murphy, M. P., Webster, N. R.   +3 more
core   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

[Ubiquinone: metabolism and functions. Ubiquinone deficiency and its implication in mitochondrial encephalopathies. Treatment with ubiquinone].

Revista de neurologia, 1999
Review of ubiquinone-10 metabolism and functions in humans, focusing its implication in the pathogenesis and physiopathology of mitochondrial encephalomyopathies.Ubiquinone-10 is an endogenously synthesized lipid with a wide distribution in tissues. Tyrosine and acetil-CoA are involved in ubiquinone biosynthesis.
Artuch-Iriberri R, Colomé C, Vilaseca MA, Pineda M, Campistol-Plana J   +4 more
openaire   +3 more sources

Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping

Environmental Toxicology, EarlyView.
ABSTRACT This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal ...
Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima   +8 more
wiley   +1 more source

The isoprenyl chain length of coenzyme Q mediates the nutritional resistance of fungi to amoeba predation

mBio
Amoebae are environmental predators feeding on bacteria, fungi, and other eukaryotic microbes. Predatory interactions alter microbial communities and impose selective pressure toward phagocytic resistance or escape which may, in turn, foster virulence ...
Nauman Saeed, Vito Valiante, Johann E. Kufs, Falk Hillmann   +3 more
doaj   +1 more source

News in Ubiquinone Biosynthesis

Chemistry & Biology, 2010
Ubiquinone (named because of its ubiquitous presence in organisms) functions as an electron carrier in the mitochondrial respiratory chain. Pierrel et al. (2010) have described the presence of new actors in the biosynthesis of this venerable molecule.
openaire   +2 more sources

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source