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The Ubiquinone-Ubiquinol Redox Cycle and Its Clinical Consequences: An Overview [PDF]
International Journal of Molecular SciencesCoenzyme Q10 (CoQ10) plays a key role in many aspects of cellular metabolism. For CoQ10 to function normally, continual interconversion between its oxidised (ubiquinone) and reduced (ubiquinol) forms is required.
David Mantle
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Vision Research, 1968
Abstract Microspectrophotometric examination of retinal cells shows an absorbance maximum at 282 nm and a shoulder at 275 nm, the latter possibly due to ubiquinone. Extraction of bovine retinal cell outer segments and retinal cells free of outer segments, however, failed to reveal any ubiquinone; an upper limit of 0.6 n mole ubiquinone per eye being ...
G, Entine, P A, Liebman, B T, Storey
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Abstract Microspectrophotometric examination of retinal cells shows an absorbance maximum at 282 nm and a shoulder at 275 nm, the latter possibly due to ubiquinone. Extraction of bovine retinal cell outer segments and retinal cells free of outer segments, however, failed to reveal any ubiquinone; an upper limit of 0.6 n mole ubiquinone per eye being ...
G, Entine, P A, Liebman, B T, Storey
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The Complexity of Making Ubiquinone
Trends in Endocrinology and Metabolism, 2019 Ubiquinone (UQ, coenzyme Q) is an essential electron transfer lipid in the mitochondrial respiratory chain. It is a main source of mitochondrial reactive oxygen species (ROS) but also has antioxidant properties. This mix of characteristics is why ubiquinone supplementation is considered a potential therapy for many diseases involving mitochondrial ...
Siegfried Hekimi, Ying Wang
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Ubiquinone Protects Cultured Neurons against Spontaneous and Excitotoxin-Induced Degeneration
Journal of Cerebral Blood Flow and Metabolism, 1992 Ubiquinone is an endogenous quinone with pharmacological actions mainly related to its antioxidant properties. Here we report that ubiquinone protects cultured cerebellar granule cells against glutamate-induced neurotoxicity.
Ferdinando Nicoletti +2 more
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1983
Publisher Summary This chapter discusses the biosynthesis of ubiquinone. Ubiquinone serves as a lipid-soluble electron carrier in the membrane-bound electron transport chains of both prokaryotes and eukaryotes. Eighty-five percent of cell ubiquinon is located in the mitochondria or equivalent membrane system.
R E, Olson, H, Rudney
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Publisher Summary This chapter discusses the biosynthesis of ubiquinone. Ubiquinone serves as a lipid-soluble electron carrier in the membrane-bound electron transport chains of both prokaryotes and eukaryotes. Eighty-five percent of cell ubiquinon is located in the mitochondria or equivalent membrane system.
R E, Olson, H, Rudney
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1967
Publisher Summary This chapter describes the chemical knowledge of the ubiquinones. It discusses new results from studies of the biosynthesis of ubiquinone, some new data concerning the mass spectrometry of the ubiquinones. Mass spectrometry has proved to be extremely useful in this research. A study of the mass spectra of a series of ubiquinones and
G D, Daves +3 more
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Publisher Summary This chapter describes the chemical knowledge of the ubiquinones. It discusses new results from studies of the biosynthesis of ubiquinone, some new data concerning the mass spectrometry of the ubiquinones. Mass spectrometry has proved to be extremely useful in this research. A study of the mass spectra of a series of ubiquinones and
G D, Daves +3 more
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Kinetics of ubiquinone reduction by the resolved succinate: Ubiquinone reductase
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1982A significant lag in the thenoyltrifluoroacetone (TTFA)-sensitive succinate: ubiquinone reductase activity was observed when a ubiquinone-deficient resolved preparation of the enzyme was assayed in the presence of exogenous ubiquinone-2 (Q2) and 2,6-dichlorophenolindophenol.
V G, Grivennikova, A D, Vinogradov
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Regulation of ubiquinone metabolism
Free Radical Biology and Medicine, 2000Interest in ubiquinone (UQ) has increased during recent years, mainly because of its antioxidant function and its use as a dietary supplement. However, our knowledge of the biosynthesis, catabolism, and regulation of this lipid in mammalian tissues is quite limited.
G, Dallner, P J, Sindelar
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Rush desensitization with ubiquinone
Allergy, 1997UBIQUINONE
Schiavino, Domenico +4 more
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On the biosynthesis of ubiquinone (50)
Archives of Biochemistry and Biophysics, 1959Abstract It is shown that radioactive mevalonic acid is utilized for the synthesis of ubiquinone in the rat. 2,3-Dimethoxy-5-methyl-1,4-benzoquinone and dl -α-tocopherol are not precursors of the quinoid ring system. With progressive vitamin A depletion, the incorporation of mevalonic acid into ubiquinone of rat liver is enhanced.
U, GLOOR, O, WISS
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