Results 31 to 40 of about 66,565 (306)

Clinical syndromes associated with Coenzyme Q10 deficiency. [PDF]

, 2018
Primary Coenzyme Q deficiencies represent a group of rare conditions caused by mutations in one of the genes required in its biosynthetic pathway at the enzymatic or regulatory level.
Alc\ue1zar-Fabra, Maria, Brea-Calvo, Gloria, Trevisson, Eva   +2 more
core   +1 more source

Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo1

Journal of Lipid Research, 1998
A randomized, double-masked, placebo-controlled cross-over trial was carried out to evaluate whether ubiquinone supplementation (180 mg daily) corrects impaired defence against initiation of oxidation of low density lipoprotein (LDL) related to effective
Ari Palomäki, Kimmo Malminiemi, Tiina Solakivi, Outi Malminiemi   +3 more
doaj   +1 more source

Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Frontiers in Bioscience-Landmark, 2022
Coenzyme Q10 (CoQ10) deficiency is broadly divided into two types, primary and secondary. Primary CoQ10 deficiencies are relatively rare disorders resulting from mutations in genes directly involved in the CoQ10 biosynthetic pathway, and are not a ...
David Mantle, Nadia Turton, Iain P. Hargreaves   +2 more
doaj   +1 more source

Fluoride Increases Superoxide Production and Impairs the Respiratory Chain in ROS 17/2.8 Osteoblastic Cells [PDF]

, 2014
It is known that fluoride produces oxidative stress. Inflammation in bone tissue and an impairment of the respiratory chain of liver have been described in treatments with fluoride. Whether the impairment of the respiratory chain and oxidative stress are
Fina, Brenda, Lombarte, Mercedes, Rigalli, Alfredo, Rigalli, Alfredo   +3 more
core   +1 more source

Ubiquinone Biosynthesis over the Entire O₂ Range: Characterization of a Conserved O₂-Independent Pathway

mBio, 2019
Most bacteria can generate ATP by respiratory metabolism, in which electrons are shuttled from reduced substrates to terminal electron acceptors, via quinone molecules like ubiquinone.
Ludovic Pelosi, Chau-Duy-Tam Vo, Sophie Saphia Abby, Laurent Loiseau, Bérengère Rascalou, Mahmoud Hajj Chehade, Bruno Faivre, Mathieu Goussé, Clothilde Chenal, Nadia Touati, Laurent Binet, David Cornu, Cameron David Fyfe, Marc Fontecave, Frédéric Barras, Murielle Lombard, Fabien Pierrel   +16 more
doaj   +1 more source

Predicting and Understanding the Pathology of Single Nucleotide Variants in Human COQ Genes

Antioxidants, 2022
Coenzyme Q (CoQ) is a vital lipid that functions as an electron carrier in the mitochondrial electron transport chain and as a membrane-soluble antioxidant.
Sining Wang, Akash Jain, Noelle Alexa Novales, Audrey N. Nashner, Fiona Tran, Catherine F. Clarke   +5 more
doaj   +1 more source

High-resolution QTL mapping in Tetranychus urticae reveals acaricide-specific responses and common target-site resistance after selection by different METI-I acaricides [PDF]

, 2019
Arthropod herbivores cause dramatic crop losses, and frequent pesticide use has led to widespread resistance in numerous species. One such species, the two-spotted spider mite, Tetranychus urticae, is an extreme generalist herbivore and a major worldwide
Bajda-Wybouw, Sabina, Clark, Richard M, Dermauw, Wannes, Feyereisen, René, Greenhalgh, Robert, Kosterlitz, Olivia, Kurlovs, Andre, Snoeck, Simon, Van Leeuwen, Thomas, Villacis-Perez, Ernesto   +9 more
core   +1 more source

Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia.

Journal of Lipid Research, 1991
Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-CoA reductase, or cholestyramine, followed by a period of combined treatment with both drugs.
PG Elmberger, A Kalén, E Lund, E Reihnér, M Eriksson, L Berglund, B Angelin, G Dallner   +7 more
doaj   +1 more source

Effects of Coenzyme Q₁₀ Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease

Antioxidants, 2022
Scarce data exist on the effects of coenzyme Q10 (CoQ10) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ10 supplementation on oxidative stress markers (glutathione ...
Natalia Druzhaeva, Alenka Nemec Svete, Gabrijela Tavčar-Kalcher, Janja Babič, Alojz Ihan, Katka Pohar, Uroš Krapež, Aleksandra Domanjko Petrič   +7 more
doaj   +1 more source

The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study

Redox Report, 2016
Objectives: To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial.
Adolfo Daniel Rodríguez-Carrizalez, José Alberto Castellanos-González, Esaú César Martínez-Romero, Guillermo Miller-Arrevillaga, Luis Miguel Román-Pintos, Fermín Paul Pacheco-Moisés, Alejandra Guillermina Miranda-Díaz   +6 more
doaj   +1 more source