Results 61 to 70 of about 66,565 (306)

A Comparative Study on the Reduction Modes for Quinone to Determine Ubiquinone by HPLC with Luminol Chemiluminescence Detection Based on the Redox Reaction

Molecules, 2022
Ubiquinone (UQ) is considered one of the important biologically active molecules in the human body. Ubiquinone determination in human plasma is important for the investigation of its bioavailability, and also its plasma level is considered an indicator ...
Naoya Kishikawa, Mahmoud El-Maghrabey, Miharu Tobo, Naotaka Kuroda   +3 more
doaj   +1 more source

A broad distribution of the alternative oxidase in microsporidian parasites [PDF]

, 2010
Microsporidia are a group of obligate intracellular parasitic eukaryotes that were considered to be amitochondriate until the recent discovery of highly reduced mitochondrial organelles called mitosomes. Analysis of the complete genome of Encephalitozoon
A Atteia, A Stechmann, AD Tsaousis, AE McDonald, AL Moore, AL Moore, AL Umbach, Anthony L. Moore, AV Goldberg, BA Williams, BA Williams, BA Williams, Bryony A. P. Williams, C Affourtit, C Larsson, C Nihei, Catherine Elliot, CH Slamovits, CR Vossbrinck, CW Roberts, DA Berthold, DE Akiyoshi, E Weidner, ES Didier, ES Didier, F Thomarat, GC Vanlerberghe, GV Beznoussenko, I Small, JA Eisen, JD Thompson, JP Huelsenbeck, K Kita, Kiyoshi Kita, Lena Burri, M Chaudhuri, M Nina, MD Katinka, MG Claros, MJ Gardner, MS Albury, MS Albury, MS Albury, N Minagawa, O Emanuelsson, P Stenmark, Patricia J. Johnson, Patrick J. Keeling, PG Crichton, PJ Didier, PJ Keeling, R George, RP Hirt, RS Cornman, S Guindon, SJ Qureshi, T Joseph-Horne, T Suzuki, TA Richards, TD Edlind, TE Elthon, TM Keane, W Jarmuszkiewicz, Y Fukai, Yasutoshi Kido   +64 more
core   +4 more sources

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

Molecular pharmacology of coenzyme Q10 in the context of treatment of hyperlipidemic conditions

Фармакоэкономика, 2023
Background. Therapy of hyperlipidemia with synthetic statin drugs is characterized by a number of side effects. In particular, statin-dependent myopathy occurs as a result of statin inhibition of biosynthesis of cofactor coenzyme Q10 (CoQ10), which plays
O. A. Gromova, I. Yu. Torshin
doaj   +1 more source

Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis [PDF]

, 2010
Peer reviewedPublisher ...
A Dhanasekaran, A Dyson, A Filipovska, AL Hill, AM James, B Bedogni, BE Minter, CA Macias, CC Chuang, CE Cross, D Brealey, D Brealey, D Brealey, D Graham, DA Lowes, DA Lowes, DP Jones, E Borrelli, ED Crouser, ED Crouser, F Arnalich, FN Gellerich, G Escames, G Escames, GF Kelso, GS Supinski, H Bayir, H Bohrer, H Zhang, HC Cowley, Helen F Galley, HF Galley, HF Galley, HF Galley, HF Goode, I Spasojević, I Vanhorebeek, J Ripcke, JC Marshall, JF Turrens, JJ Pandit, JV Esplugues, K Yassen, K Zhao, KS Roser, L Packer, M Qunitero, MD Wheeler, MD Wheeler, MP Fink, MP Fink, MP Murphy, MW Fariss, P Ghafourifar, P Wipf, RAJ Smith, RAJ Smith, RL Paterson, RO Poyton, S González-Rubio, S Rinaldi, SS Sheu, V Mishra, V Vanasco, VJ Adlam, VP Skulachev, W Droge, Z Lacza   +67 more
core   +2 more sources

Hub genes and diagnostic model associated with mitochondrial function in Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, and mitochondrial dysfunction has been confirmed in AD patients and mouse models. However, the pathogenic genes associated with AD and early diagnostic methods based on mitochondrial function remain to be explored.
Xuchao Zhu, Ling Zhang, Chuan Qin
wiley   +1 more source

Rational Engineering of Non-Ubiquinone Containing Corynebacterium glutamicum for Enhanced Coenzyme Q₁₀ Production

Metabolites, 2022
Coenzyme Q10 (CoQ10) is a lipid-soluble compound with important physiological functions and is sought after in the food and cosmetic industries owing to its antioxidant properties.
Arthur Burgardt, Ludovic Pelosi, Mahmoud Hajj Chehade, Volker F. Wendisch, Fabien Pierrel   +4 more
doaj   +1 more source

Elasticity sampling links thermodynamics to metabolic control

, 2013
Metabolic networks can be turned into kinetic models in a predefined steady state by sampling the reaction elasticities in this state. Elasticities for many reversible rate laws can be computed from the reaction Gibbs free energies, which are determined ...
Liebermeister, Wolfram
core   +2 more sources

Regulation of mitochondrial permeability transition pore by PINK1 [PDF]

, 2012
Background: Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear.
Caballero, Erica, Chan, David, Gautier, Clemente A., Glaime, Emilie, Núñez, Lucía, Shen, Jie, Song, Zhiyin, Villalobos, Carlos   +7 more
core   +3 more sources

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl, We Fong Siah, Efstratios Karavasilis, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Foteini Christidi, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source