Results 61 to 70 of about 17,360,329 (255)

Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems. [PDF]

PLoS Pathogens, 2007
The specific and covalent addition of ubiquitin to proteins, known as ubiquitination, is a eukaryotic-specific modification central to many cellular processes, such as cell cycle progression, transcriptional regulation, and hormone signaling ...
Aurélie Angot, Annette Vergunst, Stéphane Genin, Nemo Peeters   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The ubiquitin-proteasome system in glioma cell cycle control

Cell Division, 2012
A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors.
Vlachostergios Panagiotis J, Voutsadakis Ioannis A, Papandreou Christos N   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease

Frontiers in Cell and Developmental Biology
Neurodegenerative diseases are characterized by the progressive breakdown of neuronal structure and function and the pathological accumulation of misfolded protein aggregates and toxic protein oligomers.
Taylor R. Church, Seth S. Margolis, Seth S. Margolis   +2 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Viral Takeover of the Host Ubiquitin System

Frontiers in Cellular and Infection Microbiology, 2011
Like the other more well-characterized post-translational modifications (phosphorylation, methylation, acetylation, acylation, etc.), the attachment of the 76 amino acid ubiquitin (Ub) protein to substrates has been shown to govern countless cellular ...
Jean K Gustin, Ashlee V Moses, Klaus eFrüh, Janet L Douglas   +3 more
doaj   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications [PDF]

, 2013
SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation.
Jerónimo Bravo (22727), Jose L Ortega Roldan, Jerónimo Bravo, Ana I. Azuaga, Casares Atienza, Salvador, Ringkjøbing Jensen, M, van Nuland, Nico A. J., Azuaga, AI, Malene Ringkjøbing Jensen, Buday, Laszlo, Azuaga, Ana I., Ortega Roldan, Jose L., Martin Blackledge, van Nuland, Nico a J, Martin Blackledge (204261), Cárdenes, N, Nuland, Nico A. J. van, Blackledge, M, Ringkjøbing Jensen, Malene, Azuaga, Ana I, Casares, S, Salvador Casares (69741), Jensen, Malene Ringkjøbing, Ortega-Roldán, José Luis, Casares, Salvador, Nico A. J. van Nuland (116707), Bravo, J, Ortega Roldan, Jose L, Van Nuland, NAJ, Bravo, Jerónimo, Jose L. Ortega Roldan (457421), Azuaga Fortes, Ana Isabel, Ana I. Azuaga (121437), Ortega-Roldan, Jose L., Nico A J van Nuland, Jose L. Ortega Roldan, Malene Ringkjøbing Jensen (204257), Nayra Cárdenes (457422), Cárdenes, Nayra, Nico A. J. Van Nul, Ana I Azuaga, Salvador Casares, Ortega Roldan, JL, Nayra Cárdenes, Blackledge, Martin   +44 more
core   +1 more source

Auto‐Downregulation of the Florigen FT Production Prevents Precocious Flowering in Plants

Advanced Science, EarlyView.
This study shows that the leaf vein‐expressed FD complexes with the florigen FT to bind DNA motifs in FT promoter, which antagonizes CONSTANS‐mediated FT activation to feedback down‐regulate FT expression. This prevents an excessive induction of FT expression by inductive photoperiods, thereby precluding precocious transition to flowering in ...
Shu Tian, Xiao Luo, Bowen Cui, Yuehui He
wiley   +1 more source