Results 221 to 230 of about 59,465 (263)

Metabolic and post-translational modifications in sepsis-associated immune dysfunction: a conceptual framework. [PDF]

Front Immunol
Xu M, Zhang Z, Zhu M, Zhang S, Deng J, Du Z, Wang Z, Zhao H, Qiu Z.   +8 more
europepmc   +1 more source

Ubiquitin-centered post-translational modification crosstalk orchestrates tumor immunity and immunotherapy response. [PDF]

Exp Hematol Oncol
Qiao K, Wu L, Yang L, Liu M, Jiang C, Chen Y, Zhang Z, Yu J, Wei D, Xu Y.   +9 more
europepmc   +1 more source

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Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules

Acta Crystallographica Section D: Biological Crystallography, 2014
The activation of ubiquitin by the ubiquitin-activating enzyme Uba1 (E1) constitutes the first step in the covalent modification of target proteins with ubiquitin. This activation is a three-step process in which ubiquitin is adenylated at its C-terminal glycine, followed by the covalent attachment of ubiquitin to a catalytic cysteine residue of Uba1 ...
Hermann Schindelin
exaly   +3 more sources

Total Synthesis of the Ubiquitin‐Activating Enzyme Inhibitor (+)‐Panepophenanthrin.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiaoguang, Lei, Richard P, Johnson, John A, Porco   +2 more
openaire   +2 more sources

Immunocytochemical localization of ubiquitin-activating enzyme in the cell nucleus

Biochemical and Biophysical Research Communications, 1991
Ubiquitin-activating enzyme, "E1", is the first enzyme in the pathway leading to formation of ubiquitin-protein conjugates. We present immunocytochemical evidence that Ubiquitin-activating enzyme is concentrated in the cell nucleus. This finding points to the nucleus as the major site of action of this enzyme.
J C, Cook, P B, Chock
openaire   +2 more sources

Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeleton

American Journal of Physiology-Cell Physiology, 1993
Ubiquitin, a 76-amino acid protein, is covalently attached to abnormal and short-lived proteins, thus marking them for ATP-dependent proteolysis in eukaryotic cells. Ubiquitin is found within the cytoplasm, nucleus, microvilli, autophagic vacuoles, and lysosomes.
J S, Trausch, S J, Grenfell, P M, Handley-Gearhart, A, Ciechanover, A L, Schwartz   +4 more
openaire   +2 more sources

Expression, purification and characterization of human ubiquitin-activating enzyme, UBE1

Molecular Biology Reports, 2009
UBE1 plays an important role in the first step of ubiquitin-proteasome pathway to activate ubiquitin. Both the structure and biochemical property research of human UBE1 protein, and the activity analysis of those enzymes which are related with ubiquitination pathway, are based on high purity of UBE1 protein.
Mei, Zheng, Jing, Liu, Zhenxing, Yang, Xing, Gu, Fan, Li, Tiantian, Lou, Chaoneng, Ji, Yumin, Mao   +7 more
openaire   +2 more sources