Results 231 to 240 of about 59,465 (263)
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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Nature Medicine, 2018The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulators, including proteasome inhibitors and immunomodulatory imide drugs (IMiDs). Here we identified TAK-243 (
Marc L Hyer +38 more
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Panepophenanthrin, from a Mushroom Strain, a Novel Inhibitor of the Ubiquitin-Activating Enzyme
Journal of Natural Products, 2002Screening for inhibitors of the ubiquitin-proteasome pathway, considered to regulate important cellular events and linked to serious diseases as well, led to isolation of a new compound, panepophenanthrin, from the fermented broth of a mushroom strain, Panus rudis Fr. IFO 8994.
Ryuichi, Sekizawa +6 more
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The gene coding a ubiquitin-activating enzyme may locate on X chromosome
Biochemical and Biophysical Research Communications, 1988tsBN75 cells which have a ts defect in the S phase have a mutation linked to the gene of hypoxanthine phosphoribosyl transferase and cannot complement ts85 cells which have a ts defect in the ubiquitin-activating enzyme. The ubiquitin-activating enzyme may be required for completion of the S phase.
M, Ohtsubo, T, Nishimoto
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Rabbit ubiquitin-activating enzyme E1: cDNA cloning, sequence and expression
Gene, 1997A cDNA clone encoding ubiquitin-activating enzyme E1 has been isolated from a rabbit heart cDNA library and sequenced. The 3.485 kb cDNA contains an open reading frame of 1058 amino acid residues which predicts a protein of approx. 118 kDa. The deduced protein sequence exhibits a very high homology to other ubiquitin-activating enzymes identified in a ...
Sun, B. +3 more
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Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors
Bioorganic & Medicinal Chemistry Letters, 2018Ubiquitin-activating enzyme (E1), which catalyzes the activation of ubiquitin in the initial step of the ubiquitination cascade, is a potential therapeutic target in multiple myeloma and breast cancer treatment. However, only a few E1 inhibitors have been reported to date.
Yukihiro Itoh, Miki Suzuki
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The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis
Atherosclerosis, 2016The ubiquitin-activating enzyme E1 (UBA1, E1), the apex of the ubiquitin proteasome pathway, plays a critical role in protein degradation and in pathological processes. Whether UBA1 participates the development of vascular restenosis remains unknown. This study aims to determine the role of UBA1 in the development of balloon injury induced neointimal ...
Zhexue, Qin +8 more
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Mapping and expression of the ubiquitin-activating enzyme E1 (Ube1) gene in the mouse
Mammalian Genome, 1992The nucleotide sequence of the human cDNA encoding ubiquitin-activating enzyme E1 is more than 99% identical with the human A1S9T cDNA, a gene that has been shown to complement the temperature-sensitive mutant mouse cell line, tsA1S9. The amino acid sequences of the proteins encoded by these two cDNA sequences are identical, and both cDNAs were ...
C M, Disteche +5 more
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