Results 251 to 260 of about 381,302 (291)

Ubiquitin-centered post-translational modification crosstalk orchestrates tumor immunity and immunotherapy response. [PDF]

Exp Hematol Oncol
Qiao K, Wu L, Yang L, Liu M, Jiang C, Chen Y, Zhang Z, Yu J, Wei D, Xu Y.   +9 more
europepmc   +1 more source

NEMO/IKKγ: Emerging player in the NF-κB pathway and potential therapeutic target in inflammation. [PDF]

Inflammation
Karim CF, Sharifi A, Kamarul T, Genasan K.   +3 more
europepmc   +1 more source

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Nature Medicine, 2018
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulators, including proteasome inhibitors and immunomodulatory imide drugs (IMiDs). Here we identified TAK-243 (
Marc L Hyer, Michael A Milhollen, Bradley Stringer   +2 more
exaly   +4 more sources

Ubiquitin-like activating enzymes BcAtg3 and BcAtg7 participate in development and pathogenesis of Botrytis cinerea

Current Genetics, 2018
Weichao Ren, Xiu-Shi Song, Mingguo Zhou   +2 more
exaly   +2 more sources

Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules

Acta Crystallographica Section D: Biological Crystallography, 2014
The activation of ubiquitin by the ubiquitin-activating enzyme Uba1 (E1) constitutes the first step in the covalent modification of target proteins with ubiquitin. This activation is a three-step process in which ubiquitin is adenylated at its C-terminal glycine, followed by the covalent attachment of ubiquitin to a catalytic cysteine residue of Uba1 ...
Hermann Schindelin
exaly   +3 more sources

Total Synthesis of the Ubiquitin‐Activating Enzyme Inhibitor (+)‐Panepophenanthrin.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiaoguang, Lei, Richard P, Johnson, John A, Porco   +2 more
openaire   +2 more sources

E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions.

Clinica chimica acta; international journal of clinical chemistry, 2019
Despite the medical advances of the 21st century, the incidence of cancer continues to increase and the search for a universal cure remains a major health challenge.
S. M. Hosseini, Isobel S Okoye, Mitra Ghasemi Chaleshtari, Bita Hazhirkarzar, J. Mohamadnejad, G. Azizi, M. Hojjat-Farsangi, H. Mohammadi, S. Shotorbani, F. Jadidi‐Niaragh   +9 more
semanticscholar   +1 more source